Prof. Dr. Siswandono, Apt., M.S.

 

Year

Education

1978

Doktorandus, Drs., Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Indonesia

1979

Apothecary, Apt., Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Indonesia

1988

Magister of Sciences, M.S., Medicinal Chemistry, Faculty of Pascasarjana, Universitas Airlangga, Indonesia

1999

Doctor, Dr., MIPA, Medicinal Chemistry, Post Graduate Program, Universitas Airlangga, Indonesia

 

Courses

Medicinal Chemistry, Drug Design, Drug Development, Physical Chemistry, Bioinformatic. 

 

Research Interests

  • Molecular modeling, synthesis, QSAR and mechanism of action of urea and thiourea derivatives
  • Molecular modeling, synthesis and QSAR of drug derivatives (acetaminophen, salicylic and mefenamic acid)
  • Molecular modeling, synthesis, QSAR and mechanism of action of acyl and benzoyl pinostrobin derivatives
  • Study in silico of drug delivery development of pharmaceutical compounds.

 

Selected Publications

  1. Structure Modification of Ethyl p-Methoxycinnamate and Their Bioassay as Chemopreventive Agent Against Mice’s Fibrosarcoma, Juni Ekowati, Bimo A.Tejo, Shigeru Sasaki, Kimio Highasiyama, Sukardiman, Siswandono, Tutuk Budiati, 2012, International Journal of Pharmacy and Pharmaceutical Sciences, ISSN- 0975-1491, Vol. 4, Suppl. 3, pp. 528-532. Q1, https://innovareacademics.in/journal/ijpps/Vol4Suppl3.htm

  2. Uji Aktivitas Analgesik Senyawa Baru Turunan Parasetamol pada Mencit (Mus musculus) dengan Metode Hot Plate, Tri Widiandani, Siswandono, Suko Hardjono. 2013. Istifada, Risma Zahra, Berkala Ilmiah Kimia Farmasi, Vol. 2 No. 2., page: 1-4.
    ISSN 2302-8270.
    http://journal.unair.ac.id/BIKF@uji-aktivitas-analgesik-senyawa-baru-turunan-parasetamol-pada-mencit-(mus-musculus)-article-6448-media-96-category-15.html

  3. Synthesis and Antitumor Activity Evaluation of N,N’-Dibenzoyl-N,N’-Diethylurea Against Human Breast Cancer Cell Line (MCF-7), Nuzul Wahyuning Diyah, Siswandono, Juni Ekowati, International Journal of Pharmacy and Pharmaceutical Sciences, ISSN- 0975-1491 , Vol. 6, Issue. 2, pp. 315-318. Q2.
    https://innovareacademics.in/journal/ijpps/Vol6Issue2.htm

  4. Sintesis, Uji Aktivitas Sitotoksik In Vitro dan Molecular Docking Senyawa 1-(4-Klorobenzoil)-1,3-dimetilurea, DianAgung Pangaribowo, Siswandonodan Bambang Tri Purwanto, 2014, Jurnal Kimia Terapan Indonesia, Vol. 16, No. 1, hal. 33 – 37. p-ISSN: 0853-2788, e-ISSN: 2527-7669, http://inajac.lipi.go.id/index.php/InaJAC/issue/view/1 

  5. Modifikasi Struktur Dan Prediksi Aktivitas Antikanker Senyawa Baru Turunan Aliltiourea Secara In Silico, Tri Widiandani, Siswandono, 2015, Berkala Ilmiah Kimia Farmasi, Vol. 4, No. 1, pp. 35-40. ISSN 2302-8270, http://journal.unair.ac.id/BIKF@modifikasi-struktur-dan-prediksi-aktivitas-antikanker-senyawa-baru-turunan-aliltiourea-secara-in-silico-article-8787-media-96-category-15.html

  6. Synthesis and Activity Evaluation of Novel Lead Compound 1-Benzyl-3-Benzoylurea as Anti Proliferation Agent, Farida Suhud, Siswandono, Tutuk Budiati, 2015, World Journal of Pharmaceutical Science, 3 (2), pp. 192-195.
    https://www.wjpsonline.org/issue.php?id=MzA=

  7. Synthesis, Molecular Docking and Antitumor Activity Of N,N’-Carbonyl Bis(Ethylbenzamide), Nuzul Wahyuning Diyah, Bambang Tri Purwanto, Siswandono, 2015, World Journal of Pharmaceutical Science, 3 (7), pp. 1324-1329.
    https://www.wjpsonline.org/issue.php?id=MzA=

  8. N-Phenylbenzamide Synthesis by Nucleophilic Substitution with 1,3-Diphenyl-thiourea, Indah Purnama Sary, Siswandono, Tutuk Budiati, 2015, International Journal of Pharmacy and Pharmaceutical Sciences, ISSN- 0975-1491, Vol 7, Issue 3, pp. 481-482. Q2. https://innovareacademics.in/journals/index.php/ijpps/issue/view/Vol7Issue3

  9. Synthesis and in vitro Cytotoxicity of 1-Benzoyl-3-methylthiourea Derivatives, Ruswanto, Amir M. Miftah, Daryono H. Tjahjono, Siswandono, 2015, Procedia Chemistry, ISSN: 1876-6196, Vol. 17, pp. 157-161. Scimago H Index: 20 https://www.sciencedirect.com/journal/procedia-chemistry/vol/17/suppl/C

  10. Quantitative Structure-Cytotoxic Activity Relationship 1-(Benzoyloxy)urea and Its Derivative, Suko Hardjono, SiswandonoSiswodihardjo, Purwanto Pramono and Win Darmanto, 2016, Current Drug Discovery Technologies, 2016, Vol. 13, No. 2, pp. 1-8.
    ISSN: 1875-6220 (Online), 1570-1638 (Print), Scopus CiteScore Metrics: 1.72 https://benthamscience.com/journals/current-drug-discovery-technologies/volume/ 13/issue/2/

  11. Docking, Synthesis and Cytotoxicity Test on Human Breast Cancer Cell Line (T47D) of N-(Allylcarbamothioyl)benzamide, Tri Widiandani, Lusiana Arifianti, Siswandono, 2016, International Journal of Pharmaceutical and Clinical Research; 8(5)Suppl: pp. 372-376. Q3. https://ijpcr.com/volume8issue5suppl1/No. 10

  12. Synthesis and Structure-Activity Relationship of 1-Allyl-3-(2-Chlorobenzoyl) Thiourea as Analgesic, Alvan F. Shalas, Siswandono, Marcellino Rudyanto,
    International Journal of Pharmacy and Pharmaceutical Sciences, 2016, ISSN- 0975-1491 Vol 8, Issue 6, pp. 297-298. Q2.
    https://innovareacademics.in/journals/index.php/ijpps/issue/view/Vol8Issue6

  13. Method Development and Validation for The Simultaneous Determination of
    Stevioside, Rebaudioside-A, Rebaudioside C and Dulcoside A Contained in Stevia Rebaudiana Bertoni Using HPLC-ELSD, Supriyadi, Siswandono, Mochammad Yuwono, 2016, International Journal of Pharmacy and Pharmaceutical Sciences,
    ISSN- 0975-1491 Vol 8, Issue 9, pp. 1-5. Q2
    https://innovareacademics.in/journals/index.php/ijpps/issue/view/Vol8Issue9 

  14. The Role of TLR2, NF-κB, TNFα as an Inflammation Markers of Wound Dressing Combination of Zinc Oxide with Turmeric Liquid Extract, Asti Meizarini, Siswandono, Anita Yuliati, 2016, Journal of International Dental and Medical Research, ISSN 1309-100X, 9: (3), pp. 173-177. Q3.
    www.jidmr.com/journal/DENTISTRY/2016/vol9_no3/7_D16_318_Asti_Meizarini.pdf 

  15.  In Silico Study of Novel Folate Analogues as Anticancer which Inhibits Dihydrofolate Reductase., D.Y.L. Prayoga, R.A. Septiawan, E. Jingga, P.A. Hergaputra, E.C. Christiawan, R. Lusiana, R.K. Kristiwi, Siswandono, 2016, Scientific Journal of PPI-UKM, Vol. 3, No. 4, pp. 172-175. e-ISSN No: 2356-2536, p-ISSN No: 2528-6854, http://www.kemalapublisher.com/index.php/ppi-ukm/article/view/193.

  16. Identification of Physical Interaction in Binary Systems of Acyclovir-Succinic Acid, Agnes Nuniek W., Dwi Setyawan, Siswandono, 2016, Jurnal Farmasi dan Ilmu Kefarmasian Indonesia,Vol. 3 No. 1, hal. 27-31. P-ISSN:2406-9388; E-ISSN:2580-8303,
    https://e-journal.unair.ac.id/JFIKI/issue/view/470/showToc

  17. Synthesis, Molecular Docking, and Cytotoxic Activity of N-Ethyl-N-(ethylcarba-moyl)benzamide Derivatives Against MCF-7 Cell Line, Nuzul Wahyuning Diyah, S. Siswandono, Bambang Tri Purwanto, 2017, Research Journal of Pharmaceutical, Biological and Chemical Sciences, ISSN 0975-8585, 8 (1S), pp. 164-173. Q3.
    https://www.rjpbcs.com/2017_8.1S.htmlNo. 25

  18. Correlation between In Silico and In Vitro Results of 1-(Benzoyloxy)urea and Its Derivatives as Potential Anti-Cancer Drugs, Suko Hardjono, SiswandonoSiswodihardjo, Purwanto Pramono and Win Darmanto, 2017, Chemistry & Chemical Technology, ISSN: 1996-4196, Vol. 11, No 1, pp. 19-24. Q3.
    http://science2016.lp.edu.ua/chcht/vol-11-2017-1

  19. Preparation of Acyclovir-Nicotinamide Cocrystal by Solvent Evaporation Technique with Variation of Solvent, Roisah Nawatila, Agnes Nuniek W., SiswandonoSiswodihardjo, Dwi Setyawan, 2017, Asian Journal of Pharmaceutical and Clinical Research, ISSN online: 2455-3891, Vol 10, Issue 3, pp. 283-287. Q3. https://innovareacademics.in/journals/index.php/ajpcr/issue/view/263

  20. Docking and Cytotoxicity Test on Human Breast Cancer Cell Line (T47d) of N-(Allylcarbamothioyl)-3-chlorobenzamide and N-(Allylcarbamothioyl)-3, 4-dichlorobenzamide, Siswandono, Tri Widiandani, Suko Hardjono, 2017, Research Journal of Pharmaceutical, Biological and Chemical Sciences, ISSN 0975-8585, 8 (2), pp. 1909-1914. Q3. https://www.rjpbcs.com/2017_8.2.htmlNo. 209.

  21. Comparison Study of Grinding and Slurry Method on Physicochemical Characteristic of Acyclovir-Succinic Acid Cocrystal, Fauzi Rahman, Agnes Nuniek Winantari, Siswandono, Dwi Setyawan, 2017, Asian Journal of Pharmaceutical and Clinical Research, ISSN online: 2455-3891, Vol 10, Issue 3, pp. 153-158. Q3. https://innovareacademics.in/journals/index.php/ajpcr/issue/view/263

  22. Molecular Docking of 1-Benzoyl-3-Methylthiourea as Anti Cancer Candidate and Its Absorption, Distribution, and Toxicity Prediction, Ruswanto, Siswandono, Richa M, Tita N, Tresna L, 2017, Journal of Pharmaceutical Science and Research, ISSN 0975-1459, Vol. 9(5), pp. 680-684. Q3. https://www.jpsr.pharmainfo.in/issue.php?page=93

  23. Cocrystallization Acyclovir-Succinic Acid Using Solvent Evaporation Methods, Agnes Nuniek Winantari, Dwi Setyawan, SiswandonoSiswodihardjo, Sundono Nurono Soewandhi, 2017, Asian Journal Pharmaceutical Clinical Research, ISSN online: 2455-3891, Vol 10, Issue 6, pp. 91-94. Q3. https://innovareacademics.in/journals/index.php/ajpcr/issue/view/282

  24. Solid State Characterization of Acyclovir-Nicotinamide Binary Systems using Solvent Evaporation Technique, Agnes Nuniek Winantari, Dwi Setyawan, Siswandono, Sundono Nurono Soewandhi, 2017, Asian Journal of Pharmacy and Technology, Vol. 7: Issue 1, pp. 33-36. http://ajptonline.com/AbstractView.aspx?PID=2017-7-1-6

  25. Sintesis dan Uji Aktivitas Senyawa 1-Benzil-3-benzoilurea Tersubstitusi Bromo, Kloro, Floro dan Triflorometil pada posisi para sebagai Agen Antiproliferatif,
    F Suhud, Siswandono, T Budiati, 2017, Media Pharmaceutica Indonesiana, Vol. 1 (3), hal.154-163. http://journal.ubaya.ac.id/index.php/MPI/article/view/266/179

  26. Formation of Ketoprofen-Malonic Acid Cocrystal by Solvent Evaporation Method, Y Wicaksono, D Setyawan, Siswandono, 2017, Indonesian Journal of Chemistry, Vol. 17 (2), pp. 161-166. Q3. https://jurnal.ugm.ac.id/ijc/article/view/24884/16643

  27. Docking, synthesis, and cytotoxic activity of N-4-methoxybenzoyl-N’-(4-fluorophenyl)thiourea on HeLa cell line, Anindi Lupita Nasyanka, SiswandonoSiswodihardjo, Suko Hardjono, 2017, Thai Journal of Pharmaceutical Sciences, Vol. 41 (3): pp. 1-4. Q3. http://www.tjps.pharm.chula.ac.th/ojs/index.php/tjps/article/view/386/160

  28. Solvent Concentration Effect on Powder X-Ray Diffraction and Dissolution Profiles of Acyclovir-Nicotinamide Cocrystals, D Setiawan, Siswandono, Agnes Nuniek Winantari, Zu’aimah K, 2017, International Journal of Drug Delivery Technology; Vol. 7(4); pp. 310-313. Q3.
    http://impactfactor.org/PDF/IJDDT/7/IJDDT,Vol7,Issue4,Article9.pdf

  29. Synthesis and Pain Inhibition Activity of the Analogs of 1-Allyl-3-Benzoylthiourea for New Analgesic Lead Compound Discovery, Alvan F. Shalas, Siswandono, Marcellino Rudyanto, 2018, Journal of Young Pharmacists, Vol. 10(1), pp. 12-15. 2017: Q2, SJR: 0,31, ISSN: Print -0975-1483, Online - 0975-1505, DOI: 10.5530/jyp.2018.10.4 http://www.jyoungpharm.org/v10/i1

  30. In silico and in vivo anti-imflamatory studies of curcuminoids, turmeric extract with zinc oxide, and eugenol, Asti Meizarini, Siswandono, Wibi Riawan, Retno P Rahayu, 2018, Tropical Journal of Pharmaceutical Research, Vol. 17 (2), pp. 269-275. 2017, Q3, SJR: 0,26.
    https://www.tjpr.org/home/achieve.php?vol=17&no=2&yr=2018

  31. Uji in silico Aktivitas Sitotoksik dan Toksisitas Senyawa Turunan N-(Benzoil)-N’- feniltiourea Sebagai Calon Obat Antikanker, Dini Kesuma, Siswandono, Bambang Tri Purwanto, dan Suko Hardjono, 2018, Journal of Pharmaceutical Science and Clinical Research, 2018, Vol.3(1), hal. 1-11. DOI: 10.20961/jpscr.v3i1.16266, eISSN: 2503-331X, https://jurnal.uns.ac.id/jpscr/article/view/16266

  32. Docking, Synthesis, and Cytotoxic Test on Human Breast Cancer Cell line T47D of N-(Phenylcarbamothioyl)benzamide, Dini Kesuma, Siswandono, Bambang Tri Purwanto, and Marcellino Rudyanto, 2018, World Journal of Pharmaceutical Research, Vol. 7 (7), pp. 70-78., DOI: 10.20959/wjpr20187-11474. ISSN: 2277-7105, http://www.wjpr.net/dashboard/archive_show/2018/VOLUME%207,%20APRIL%20ISSUE%207

  33. 1-(4-Hexylbenzoyl)-3-methylthiourea, Ruswanto Ruswanto, Richa Mardianingrum, Tresna Lestari, Tita Nofianti, Siswandono, 2018, Molbank M1005; doi:10.3390/M1005, 2018, Issue 3, pp.1-5.(Scopus) Q4, ISSN 1422-8599; CODEN: MOLBAI, SJR: 0,25, https://www.mdpi.com/1422-8599/2018/3

  34. Phase Diagram and Thermodynamic Properties of Ketoprofen-Succinic Acid Binary Mixtures, Yudi Wicaksono, Dwi Setyawan, Siswandono,  2018, Jurnal ILMU DASAR, Vol.19, No. 2, pp. 99-104. Terakreditasi DIKTI, Terindeks Copernicus, eISSN: 2442-5612, pISSN: 1411-5735
    https://jurnal.unej.ac.id/index.php/JID/article/view/5521

  35. Synthesis of N-(phenylcarbamothioyl)-benzamide derivatives and their cytotoxic activity against MCF-7 cells, Dini Kesuma, Siswandono, Bambang Tri Purwanto, Marcellino Rudyanto, 2018, Journal of Chinese Pharmaceutical Sciences, Vol.27(10): 696-702, DOI: 10.5246/jcps.2018.10.071. Q3, SJR: 0,17, http://www.jcps.ac.cn/EN/volumn/volumn_1281.shtml

  36. Molecular Docking of Ferulic Acid Derivatives on P2Y12 Receptor and their ADMET Prediction, Juni Ekowati, Nuzul Wahyuning Diyah, Kholis Amalia Nofianti, Iwan Sahrial Hamid & Siswandono, 2018, Journal of Mathematical and Fundamental Sciences; Vol. 50, No. 2: 203-219, ISSN: 2338-5510, 2337-5760, Q3: SJR: 0,17. http://journals.itb.ac.id/index.php/jmfs/issue/view/550

  37. New N-allylthiourea derivatives: Synthesis, molecular docking and in vitro cytotoxicity studies, Tri Widiandani, Siswandono, Edy Meiyanto, Melanny Ika Sulistyowaty, Bambang Tri Purwanto, Suko Hardjono, 2018, Tropical Journal of Pharmaceutical Research, Vol. 17 (8): 1607-1613, SJR: 0,26, Q3, ISSN: 1596-5996 (print); 1596-9827 (electronic), http://dx.doi.org/10.4314/tjpr.v17i8.20.

  38. Multicomponent Crystallization of Ketoprofen-Nicotinamide for Improving the Solubility and Dissolution Rate, Yudi Wicaksono, Dwi Setyawan, Siswandono, 2018, Chemistry Journal Of Moldova. General, Industrial and Ecological Chemistry. Vol.13(2), 74-81. ISSN (p) 1857-1727 ISSN (e) 2345-1688. Q4.
    http://cjm.asm.md/taxonomy/term/43

  39. Preparation and Characterization of a Novel Cocrystal of Atorvastatin Calcium with Succinic Acid Coformer - Yudi Wicaksono, Dwi Setyawan, Siswandono, Tri Agus Siswoyo,  2019, Indonesian Journal of Chemistry, Vol. 19 (3), pp. 660-667. ISSN: 1411- 9420, eISSN: 2460-1578, Q3.
    http://pdm-mipa.ugm.ac.id/ojs/index.php/ijc

  40. Ferulic Acid Prevents Angiogenesis Through Cyclooxygenase-2 and Vascular Endothelial Growth Factor on The Chick Embryo Chorioallantoic Membrane Model, Juni Ekowati, Iwan Sahrial Hamid, Nuzul Wahyuning Diyah, S Siswandono, 2019,  DOI: 10.4274/tjps.galenos.2019.44712, Turkish Journal of Pharmaceutical Sciences, ISSN: 1304-530X E-ISSN:2148-6247, SJR = 0,16. Q3. (Accepted)

  41. Co-crystallization of quercetin and isonicotinamide using solvent evaporation method, Budipratiwi Wisudyaningsih, Dwi Setyawan, Siswandono, 2019, Tropical Journal of Pharmaceutical Research, Vol. 18 (4): 697-702, SJR: 0,26, Q3, ISSN: 1596-5996 (print); 1596-9827 (electronic).
    http://dx.doi.org/10.4314/tjpr.v18i4.3

Contact

Prof. Dr. Siswandono, Apt., M.S.

E-mail  sis_ffua@yahoo.com

Email Instansi  siswandono@ff.unair.ac.id 


Unduhan