Prof. apt. Rr. Retno Widyowati, S.Si.,M.Pharm.,Ph.D.

Courses

Pharmaceutical Botany, Pharmacognosy, Phytochemistry, Phytopharmacy

Profiles

• Sinta Profile
• Scopus Profile

Research Interests

• Investigation of chemical compounds in several Indonesia Medicinal plants
• Exploring anti-osteoporosis activity from natural products
• Exploring anti-aging activity from natural products
• Exploring anti-diabetic activity from natural products

Selected Publications

1. Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis; Journal of Public Health in Africa; 2023

2. Effects of Eleutherine bulbosa (mill.) urb. bulb extract on mice glucocorticoid-induced osteoporosis models; Journal of Public Health in Africa; 2023

3. Viability of ?-mangostin and Lipopolysaccharide (LPS) in 7F2 Cells; Tropical Journal of Natural Product Research; 2023

4. ACUTE TOXICITY ASSESSMENT OF GRAPTOPHYLLUM PICTUM (L.) GRIFF. LEAVES ETHANOLIC EXTRACT AND ITS NANOFORMULATIONS: COMPARATIVE STUDY OF PHYTOSOME AND CYCLODEXTRIN INCLUSION COMPLEX; Farmacia; 2023

5. The pro-inflammatory cytokine IL-I? alteration by deer (Rusa unicolor) antler extract on osteoarthritis rat model; Saudi Pharmaceutical Journal; 2023

6. The Potential of ?-mangostin on TNF-? and OSX Expression Post Inflammation Induction on Osteoblast: An Experimental In Vitro Study; Journal of International Dental and Medical Research; 2022

7. Advances in Hybrid Vesicular-based Drug Delivery Systems: Improved Biocompati-bility, Targeting, Therapeutic Efficacy and Pharmacokinetics of Anticancer Drugs; Current Drug Metabolism; 2022

8. Chlorogenic Acid Fractionation in Robusta Green Bean Extract as a Combination Agent of Dental Pulp Stem Cells in Periodontal Tissue Engineering; Research Journal of Pharmacy and Technology; 2022

9. Molecular Docking Estrogen Receptor Alpha Antagonist and P53-MDM2 Inhibitor, ADMET Prediction of Alkaloid Compound from Mitragyna speciosa for Breast Cancer Therapy; Pharmacognosy Journal; 2022

10. In vitro Antioxidant and Anticholinesterase Activities of Extracts from the Leaves of Cassia moschata Kunth; Research Journal of Pharmacy and Technology; 2022

11. Hadi Poerwono, Retno Widyowati, Hajime Kubo, Kimio Higashiyama, Gunawan Indrayanto, 2005, Mefenamic acid: Analytical Profile, Profiles of Drug Substances, Excipients and Related Methodology, ISSN: 1871-5125, 31, 281 – 336, Elsevier Academic Press, https://www.sciencedirect.com/bookseries/profiles-of-drug-substances-excipients-and-related-methodology/vol/31

12. Tomohito Hamazaki, Nobuo Suzuki, Retno Widyowati, Tatsuro Miyahara, Shigetoshi Kadota, Hiroshi Ochiai, Kei Hamazaki, 2009, The Depressive Effects of 5,8,11-Eicosatrienoic Acid (20:3n-9) on Osteoblasts, Lipids, ISSN: 0024-4201 (P); 1558-9307 (O), 44 (2), 97 – 102, https://link.springer.com/article/10.1007/s11745-008-3252-8

13. Retno Widyowati, Yasuhiro Tezuka, Tatsuro Miyahara, Suresh Awale, Shigetoshi Kadota, 2010, Alkaline Phosphatase (ALP) Enhancing Iridoid Glucosides from The Indonesian Medicinal Plant Barleria lupulina, Natural Product Communications, ISSN:,1555-9475 (P); 1934-578X (O), 5 (11), 1711 – 1716 https://www.ncbi.nlm.nih.gov/pubmed/21213964

14. Retno Widyowati, 2011, Alkaline Phosphatase Activity of Graptophyllum pictum and Sphilanthes acmella Fractions againts MC3T3-E1 Cells as Marker of Osteoblast Differentiation Cells, International Journal of Pharmacy and Pharmaceutical Sciences, ISSN: 0975-1491, 3 (1), 34–37, https://innovareacademics.in/journal/ijpps/Vol3Suppl1/7.pdf

15. Retno Widyowati, Marta Ika Riyana, Hening Laswati, Mangestuti Agil, 2013, Efek Pemberian Ekstrak Etanol 70% Barleria lupulina Lindl dan Kombinasi Latihan Fisik pada Mencit yang Diinduksi Deksametason, Jurnal Bahan Alam Indonesia, ISSN: 1412-2855, 8 (1), 58–61, https://garuda.ristekdikti.go.id/journal/article/62728

16. Hening Laswati, Imam Subadi, Retno Widyowati, Mangestuti Agil, Jahya Alex Pangkahila, 2015, Spilanthes acmella and Physical Exercise Increased Testosterone Levels and Osteoblast Cells in Glucocorticoid-Induced Osteoporosis Male Mice, Bali Medical Journal, ISSN: 2089-1180 (P); 2302-2914 (O), 4 (2), 76 – 81,
    https://www.balimedicaljournal.org/index.php/bmj/article/viewFile/124/223

17. Retno Widyowati, Sachiko Sugimoto, Yoshi Yamano, Sukardiman, Hideaki Ostuka, Katsuyoshi Matsunami, 2015, New Cis-ent-clerodane from Linaria japonica, Phytochemistry letters, ISSN: 1874-3900, 14 (12), 56 – 62,
    https://www.sciencedirect.com/science/article/pii/S1874390015300616

18. Juni Ekowati, S.D. Rahman, Dewi Isadiartuti, Retno Widyowati, Tutuk Budiati, 2016, Synthesis of Ferulic Acid and its Non Covalent Inclusion with Hydroxypropyl--cyclodextrin, International Journal of Pharmaceutical and Clinical Research, ISSN: 0975-1556, 8 (3), 198 – 205, https://impactfactor.org/PDF/IJPCR/8/IJPCR,Vol8,Issue3,Article9.pdf

19. Retno Widyowati, Sachiko Sugimoto, Yoshi Yamano, Sukardiman, Hideaki Ostuka, Katsuyoshi Matsunami, 2016, New Isolinariin C, D and E, Flavonoid Glycosides from Linaria japonica, Chemical & Pharmaceutical Bulletin, ISSN: 1347-5223 (P); 0009-2363 (O), 64 (5), 517 – 521, https://www.jstage.jst.go.jp/article/cpb/64/5/64_c16-00073/_article/-char/en

20. Juni Ekowati, Retno Widyowati, Dewi Isadiartuti, 2017, Preparation of An Inclusion Complex System of Ethyl p-Methoxycinnamate-Hydroxypropyl-β-Cyclodextrin: Characterization and Solubility Evaluation, Research Journal of Pharmaceutical, Biological and Chemical Sciences, ISSN: 0975-8585, 8 (1), 1486 – 1494, https://www.rjpbcs.com/pdf/2017_8(1)/[186].pdf

21. Retno Widyowati, Mangestuti Agil, 2018, Chemical Constituents and Bioactivities of Several Indonesian Plants Typically Used in Jamu, Chemical & Pharmaceutical Bulletin, ISSN: 1347-5223 (P); 0009-2363 (O), 66 (5), 506 – 518, https://www.jstage.jst.go.jp/article/cpb/66/5/66_c17-00983/_article/-char/en

22. Idha Kusumawati, Kresma Oky Kurniawan, Subhan Rullyansyah, Tri Anggono Prijo, Retno Widyowati, Juni Ekowati, Eka Pramyrtha Hestianah, Suprapto Maat, Katsuyoshi Matsunami, 2018, Anti-aging Properties of Curcuma heyneana Valeton & Zipj: A Scientific Approach to Its Use in Javanese Tradition, Journal of Ethnopharmacology, ISSN: 0378-8741, 225, 64 – 70, https://ac.els-cdn.com/S0378874118305221/1-s2.0-S0378874118305221 main.pdf?_tid=fd3e2819-ac22-4100-9211 d6f5caf4bc63&acdnat=1537335012_0050bf4c7798fb21dbf7d390ede48123

23. Dewi Melani Hariyadi, Dwi Setyawan, Suciati, Retno Widyowati, Hshin-I Chang, IPG Ngurah Suryawan, Agung Widi Utama, 2019, Extraction and Preformulation Study of Deer Antler Velvet Extract: Physical Characterization of Aqueous and Ethanol Extract, International Journal of Drug Delivery Technology, ISSN: 0975 4415, 9 (2), 151 – 159,
    https://ijddt.com/volume9issue2/

24. Juni Ekowati, Retno Widowati and Dewi Isadiartuti, Preparation Of An Inclusion Complex System OfEthyl PMethoxycinnamate - Hydroxypropyl-ß-Cyclodextrin: Characterization and Solubility Evaluation. January – February 2017 RJPBCS 8(1) Page No. 1486-1494
    
    
25. Al-Joufi, F. A., Setia, A., Salem-Bekhit, M. M., Sahu, R. K., Alqahtani, F. Y., Widyowati, R., & Aleanizy, F. S. (2022). Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as NanotechnologyBased Diagnostic and Therapeutic Approaches. Nanomaterials (Basel, Switzerland), 12(1). https://doi.org/10.3390/nano12010169
    
    
26. Suciati, S., Rizqiyah, W., Inayah, D., Widyowati, R., Ekasari, W., & Suphrom, N. (2022). In vitro Antioxidant and Anticholinesterase Activities of Extracts from the Leaves of Cassia moschata Kunth. Research Journal of Pharmacy and Technology, 1749–1754. https://doi.org/10.52711/0974-
    360X.2022.00293
    
    
27. Irawati, N., Widyowati, R., Kopeuw, P., & Wardoyo, B. P. E. (2022). Ethnomedicine Study on Justicia gendarussa for Male Contraception at the Nimboran Ethnic, Jayapura. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 9(1), 55–61. https://doi.org/10.20473/jfiki.v9i12022.55-61
    
    
28. Kanina, L., Solehah, M., Plumeriastuti, H., Widyowati, R., & Wardoyo, B. (2022). Acute and Subchronic Toxicity Assessment of 70% Ethanol Extract of Gendarusa Leaves In Vivo. JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA, 9, 39–47. https://doi.org/10.20473/jfiki.v9i12022.39-47

Contact

Prof. apt. Rr. Retno Widyowati, S.Si.,M.Pharm.,Ph.D.

E-mail retno_biotek@yahoo.com

E-mail Instansi rr-retno-w@ff.unair.ac.id