info@ff.unair.ac.id +62-31-5937824

Prof. apt. Rr. Retno Widyowati, S.Si.,M.Pharm.,Ph.D.

Year

Education

2001

Bachelor of Science, S.Si., Natural Product Department, Faculty of Pharmacy, Universitas Airlangga, Indonesia

2002

Apothecary, Apt., Faculty of Pharmacy, Universitas Airlangga, Indonesia

2009

Master of Pharmaceutical Science, M.Pharm., Institute of Natural Products Medicine, University of Toyama, Japan

2016

Doctor of Philosophy, Ph.D., Graduate School and Biomedical Science, Hiroshima University, Japan

 

Courses

Pharmaceutical Botany, Pharmacognosy, Phytochemistry, Phytopharmacy

 

Profiles

 

Research Interests

  • Investigation of chemical compounds in several Indonesia Medicinal plants
  • Exploring anti-osteoporosis activity from natural products
  • Exploring anti-aging activity from natural products
  • Exploring anti-diabetic activity from natural products

 

Selected Publications

  1. Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis; Journal of Public Health in Africa; 2023

  2. Effects of Eleutherine bulbosa (mill.) urb. bulb extract on mice glucocorticoid-induced osteoporosis models; Journal of Public Health in Africa; 2023

  3. Viability of ?-mangostin and Lipopolysaccharide (LPS) in 7F2 Cells; Tropical Journal of Natural Product Research; 2023

  4. ACUTE TOXICITY ASSESSMENT OF GRAPTOPHYLLUM PICTUM (L.) GRIFF. LEAVES ETHANOLIC EXTRACT AND ITS NANOFORMULATIONS: COMPARATIVE STUDY OF PHYTOSOME AND CYCLODEXTRIN INCLUSION COMPLEX; Farmacia; 2023

  5. The pro-inflammatory cytokine IL-I? alteration by deer (Rusa unicolor) antler extract on osteoarthritis rat model; Saudi Pharmaceutical Journal; 2023

  6. The Potential of ?-mangostin on TNF-? and OSX Expression Post Inflammation Induction on Osteoblast: An Experimental In Vitro Study; Journal of International Dental and Medical Research; 2022

  7. Advances in Hybrid Vesicular-based Drug Delivery Systems: Improved Biocompati-bility, Targeting, Therapeutic Efficacy and Pharmacokinetics of Anticancer Drugs; Current Drug Metabolism; 2022

  8. Chlorogenic Acid Fractionation in Robusta Green Bean Extract as a Combination Agent of Dental Pulp Stem Cells in Periodontal Tissue Engineering; Research Journal of Pharmacy and Technology; 2022

  9. Molecular Docking Estrogen Receptor Alpha Antagonist and P53-MDM2 Inhibitor, ADMET Prediction of Alkaloid Compound from Mitragyna speciosa for Breast Cancer Therapy; Pharmacognosy Journal; 2022

  10. In vitro Antioxidant and Anticholinesterase Activities of Extracts from the Leaves of Cassia moschata Kunth; Research Journal of Pharmacy and Technology; 2022

  11. Hadi Poerwono, Retno Widyowati, Hajime Kubo, Kimio Higashiyama, Gunawan Indrayanto, 2005, Mefenamic acid: Analytical Profile, Profiles of Drug Substances, Excipients and Related Methodology, ISSN: 1871-5125, 31, 281 – 336, Elsevier Academic Press, https://www.sciencedirect.com/bookseries/profiles-of-drug-substances-excipients-and-related-methodology/vol/31

  12. Tomohito Hamazaki, Nobuo Suzuki, Retno Widyowati, Tatsuro Miyahara, Shigetoshi Kadota, Hiroshi Ochiai, Kei Hamazaki, 2009, The Depressive Effects of 5,8,11-Eicosatrienoic Acid (20:3n-9) on Osteoblasts, Lipids, ISSN: 0024-4201 (P); 1558-9307 (O), 44 (2), 97 – 102, https://link.springer.com/article/10.1007/s11745-008-3252-8

  13. Retno Widyowati, Yasuhiro Tezuka, Tatsuro Miyahara, Suresh Awale, Shigetoshi Kadota, 2010, Alkaline Phosphatase (ALP) Enhancing Iridoid Glucosides from The Indonesian Medicinal Plant Barleria lupulina, Natural Product Communications, ISSN:,1555-9475 (P); 1934-578X (O), 5 (11), 1711 – 1716 https://www.ncbi.nlm.nih.gov/pubmed/21213964

  14. Retno Widyowati, 2011, Alkaline Phosphatase Activity of Graptophyllum pictum and Sphilanthes acmella Fractions againts MC3T3-E1 Cells as Marker of Osteoblast Differentiation Cells, International Journal of Pharmacy and Pharmaceutical Sciences, ISSN: 0975-1491, 3 (1), 34–37, https://innovareacademics.in/journal/ijpps/Vol3Suppl1/7.pdf

  15. Retno Widyowati, Marta Ika Riyana, Hening Laswati, Mangestuti Agil, 2013, Efek Pemberian Ekstrak Etanol 70% Barleria lupulina Lindl dan Kombinasi Latihan Fisik pada Mencit yang Diinduksi Deksametason, Jurnal Bahan Alam Indonesia, ISSN: 1412-2855, 8 (1), 58–61, https://garuda.ristekdikti.go.id/journal/article/62728

  16. Hening Laswati, Imam Subadi, Retno Widyowati, Mangestuti Agil, Jahya Alex Pangkahila, 2015, Spilanthes acmella and Physical Exercise Increased Testosterone Levels and Osteoblast Cells in Glucocorticoid-Induced Osteoporosis Male Mice, Bali Medical Journal, ISSN: 2089-1180 (P); 2302-2914 (O), 4 (2), 76 – 81,
    https://www.balimedicaljournal.org/index.php/bmj/article/viewFile/124/223

  17. Retno Widyowati, Sachiko Sugimoto, Yoshi Yamano, Sukardiman, Hideaki Ostuka, Katsuyoshi Matsunami, 2015, New Cis-ent-clerodane from Linaria japonica, Phytochemistry letters, ISSN: 1874-3900, 14 (12), 56 – 62,
    https://www.sciencedirect.com/science/article/pii/S1874390015300616

  18. Juni Ekowati, S.D. Rahman, Dewi Isadiartuti, Retno Widyowati, Tutuk Budiati, 2016, Synthesis of Ferulic Acid and its Non Covalent Inclusion with Hydroxypropyl--cyclodextrin, International Journal of Pharmaceutical and Clinical Research, ISSN: 0975-1556, 8 (3), 198 – 205, https://impactfactor.org/PDF/IJPCR/8/IJPCR,Vol8,Issue3,Article9.pdf

  19. Retno Widyowati, Sachiko Sugimoto, Yoshi Yamano, Sukardiman, Hideaki Ostuka, Katsuyoshi Matsunami, 2016, New Isolinariin C, D and E, Flavonoid Glycosides from Linaria japonica, Chemical & Pharmaceutical Bulletin, ISSN: 1347-5223 (P); 0009-2363 (O), 64 (5), 517 – 521, https://www.jstage.jst.go.jp/article/cpb/64/5/64_c16-00073/_article/-char/en

  20. Juni Ekowati, Retno Widyowati, Dewi Isadiartuti, 2017, Preparation of An Inclusion Complex System of Ethyl p-Methoxycinnamate-Hydroxypropyl-β-Cyclodextrin: Characterization and Solubility Evaluation, Research Journal of Pharmaceutical, Biological and Chemical Sciences, ISSN: 0975-8585, 8 (1), 1486 – 1494, https://www.rjpbcs.com/pdf/2017_8(1)/[186].pdf

  21. Retno Widyowati, Mangestuti Agil, 2018, Chemical Constituents and Bioactivities of Several Indonesian Plants Typically Used in Jamu, Chemical & Pharmaceutical Bulletin, ISSN: 1347-5223 (P); 0009-2363 (O), 66 (5), 506 – 518, https://www.jstage.jst.go.jp/article/cpb/66/5/66_c17-00983/_article/-char/en

  22. Idha Kusumawati, Kresma Oky Kurniawan, Subhan Rullyansyah, Tri Anggono Prijo, Retno Widyowati, Juni Ekowati, Eka Pramyrtha Hestianah, Suprapto Maat, Katsuyoshi Matsunami, 2018, Anti-aging Properties of Curcuma heyneana Valeton & Zipj: A Scientific Approach to Its Use in Javanese Tradition, Journal of Ethnopharmacology, ISSN: 0378-8741, 225, 64 – 70, https://ac.els-cdn.com/S0378874118305221/1-s2.0-S0378874118305221 main.pdf?_tid=fd3e2819-ac22-4100-9211 d6f5caf4bc63&acdnat=1537335012_0050bf4c7798fb21dbf7d390ede48123

  23. Dewi Melani Hariyadi, Dwi Setyawan, Suciati, Retno Widyowati, Hshin-I Chang, IPG Ngurah Suryawan, Agung Widi Utama, 2019, Extraction and Preformulation Study of Deer Antler Velvet Extract: Physical Characterization of Aqueous and Ethanol Extract, International Journal of Drug Delivery Technology, ISSN: 0975 4415, 9 (2), 151 – 159,
    https://ijddt.com/volume9issue2/

  24. Juni Ekowati, Retno Widowati and Dewi Isadiartuti, Preparation Of An Inclusion Complex System OfEthyl PMethoxycinnamate - Hydroxypropyl-ß-Cyclodextrin: Characterization and Solubility Evaluation. January – February 2017 RJPBCS 8(1) Page No. 1486-1494

  25. Al-Joufi, F. A., Setia, A., Salem-Bekhit, M. M., Sahu, R. K., Alqahtani, F. Y., Widyowati, R., & Aleanizy, F. S. (2022). Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as NanotechnologyBased Diagnostic and Therapeutic Approaches. Nanomaterials (Basel, Switzerland), 12(1). https://doi.org/10.3390/nano12010169

  26. Suciati, S., Rizqiyah, W., Inayah, D., Widyowati, R., Ekasari, W., & Suphrom, N. (2022). In vitro Antioxidant and Anticholinesterase Activities of Extracts from the Leaves of Cassia moschata Kunth. Research Journal of Pharmacy and Technology, 1749–1754. https://doi.org/10.52711/0974-
    360X.2022.00293

  27. Irawati, N., Widyowati, R., Kopeuw, P., & Wardoyo, B. P. E. (2022). Ethnomedicine Study on Justicia gendarussa for Male Contraception at the Nimboran Ethnic, Jayapura. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 9(1), 55–61. https://doi.org/10.20473/jfiki.v9i12022.55-61

  28. Kanina, L., Solehah, M., Plumeriastuti, H., Widyowati, R., & Wardoyo, B. (2022). Acute and Subchronic Toxicity Assessment of 70% Ethanol Extract of Gendarusa Leaves In Vivo. JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA, 9, 39–47. https://doi.org/10.20473/jfiki.v9i12022.39-47

 

Contact

Prof. apt. Rr. Retno Widyowati, S.Si.,M.Pharm.,Ph.D.

E-mail retno_biotek@yahoo.com

E-mail Instansi rr-retno-w@ff.unair.ac.id