Prof. Dr. Juni Ekowati, M.Si.,Apt

Profiles

• Sinta Profile
• Scopus Profile

Courses

Organic Chemistry, Physical Organic Chemistry, Basic Physics, Basic Chemistry, Pharmaceutical Synthesis, Natural Organic Chemistry. 

Research Interests

• Development of natural sources for drug candidate
• Investigations of bioactive compounds by organic synthesis and semi synthesis reaction
• Applications of in silico modelling to Drug design
• Development synthesis method of drug candidate
• Bioassay of cancer chemoprevention, anticancer, analgesic, antiangiogenesis, antiplatelet activity

Selected Publications

1. Juni Ekowati, Nuzul Wahyuning Diyah, Achmad Syahrani. 2019. Synthesis and Antiplatelet Activities of Some Derivatives of p-Coumaric Acid, Chem. Chem. Technol., 13(3), 296-302. DOI:10.23939/chcht13.03.296. https://www.researchgate.net/publication/334467428_Synthesis_and_Antiplatelet_Activites_of_Some_Derivatives_of_p-Coumaric_Acid

2. Juni Ekowati, Iwan Syahrial Hamid, Kholis Amalia Nofianti, Shigeru Sasaki. 2019. Synthesis of Thiourea Derivatives from m-Methoxycinnamic Acid as Antiangiogenic Candidate, Jurnal Teknologi, 81(4) , 105–114 | www.jurnalteknologi.utm.my | eISSN 2180–3722 |DOI: https://doi.org/10.11113/jt.v81.13410| https://jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/13410

3. Juni Ekowati Ferulic Acid Prevents Angiogenesis Through Cyclooxygenase-2 and Vascular Endothelial Growth Factor on The Chick Embryo Chorioallantoic Membrane Model, TJPS, 2020 (in process to publish) DOI: 10.4274/tjps.galenos.2019.44712. https://www.turkjps.org/archives/archive-detail?vid=2326

4. Idha Kusumawati, KO Kurniawan, S Rulliansyah, TA Prijo, Retno Widyowati, Juni Ekowati, EP Hestianah, Suprapto Maat, K Matsunami. 2018. Anti-aging properties of Curcuma heyneana Valeton & Zipj: A scientific approach to its use in Javanese tradition, Journal of Ethnopharmacology, 225:64-70. doi: 10.1016/j.jep.2018.06.038 https://www.ncbi.nlm.nih.gov/pubmed/30008394 .

5. Rizki Amalia Adlina Affandhi, Juni Ekowati, Noor Erma Nasution. 2018. Extraction, Isolation and Analysis of Chondroitin Sulphate from Chicken Shank by Spectrophotometric Method, Research J. Pharm. and Tech, 11(12) :5327. DOI: 10.5958/0974-360X.2018.00969.1 https://www.researchgate.net/publication/333187485_Extraction_Isolation_and_Analysis_of_Chondroitin_Sulphate_from_Chicken_Shank_by_Spectrophotometric_Method

6. Juni Ekowati, Nuzul Wahyuning Diyah, Kholis Amalia Nofianti, Iwan Sahrial Hamid, Siswandono. 2018. Molecular Docking of Ferulic Acid Derivatives on P2Y12 Receptor and their ADMET Prediction, Journal Mathematical and Fundamental Sciences, 50(2), 203-219. ISSN: 2337-5760, DOI: 10.5614/j.math.fund.sci.2018.50.2.8 https://journals.itb.ac.id/index.php/jmfs/article/view/6448/3295

7. Tanaya Djati Dharma Dewi, Juni Ekowati. 2017. Design, Synthesis and Analgesic Activity of 3-ChlorobenzoylN-(2-amino-4-chlorophenyl) anthranilic acid, International Journal of Pharmaceutical Chemistry, 07(12), 162-166. https://ssjournals.com/index.php/ijpc/article/view/4618/3136

8. Juni Ekowati, Retno Widyowati, Dewi Isadiartuti. 2017. Preparation of an inclusion complex system of ethyl p-methoxycinnamate -hydroxypropyl-β-cyclodextrin: Characterization and solubility evaluation, Research Journal of Pharmaceutical, Biological and Chemical Sciences, 8(1), 1486-1494.https://www.rjpbcs.com/pdf/2017_8(1)/[186].pdf

9. Galih Satrio Putra, Anita Puspa Widiyana, Luthfi Ahmad Muchlashi, Mellany Ika Sulistyowaty, Juni Ekowati and Tutuk Budiati. 2017. The influence of ratio pyridine and triethylamine catalysts on synthesis 2-Phenyl-Benzo[D] [1,3] Oxazine-4-on derivatives, Journal of Chemical and Pharmaceutical Research, 9(8),73-80. https://www.jocpr.com/articles/the-influence-of-ratio-pyridine-and-triethylamine-catalysts-on-synthesis-2phenylbenzod-13-oxazine4on-derivatives.pdf

10. Galih Satrio Putra, Melanny Ika Sulistyowati, Juni Ekowati, Tutuk Budiati. 2017. Molecular modelling and in silico analysis of p-methoxycinnamoyl hydrazide analogues as Checkpoint Kinase-1 and aromatase inhibitors, Pharm Sci Res, 4(2), 66-80. https://www.researchgate.net/publication/319706783_Pemodelan_Molekul_Turunan_p-Metoksi_sinnamoil_Hidrazida_Sebagai_Inhibitor_Checkpoint_Kinase_1_dan_Inhibitor_Aromatase_secara_In_silico

11. Juni Ekowati, Septri D Rahman, Dewi Isadiartuti, Retno Widyowati, Tutuk Budiati. 2016. Synthesis of Ferulic Acid and Its Non Covalent Inclusion with Hydroxypropyl-b-cyclodextrin, IJPCR, 8(3), 198-205. https://ijpcr.com/volume8issue3/.

12. Melanny Ika Sulistyowati, AE Nugroho, Galih S Putra, Juni Ekowati, Tutuk Budiati. 2016. Syntheses, Molecular Docking Study and Anticancer Activity Examination of p-Methoxycinnamoyl Hydrazides, IJPCR, 8(6), 623-627. https://www.ijpcr.com.

13. Melanny Ika Sulistyowati, Kholis Amalia Nofianti, Juni Ekowati, Galih S Putra, Tri Widiandani, Tutuk Budiati. 2015. Antibacterial and Antioxidant Activity Evaluation of 1, 3-Diaryl-prop-2-en-1-one Derivatives. Procedia Chemistry, 16, 372-375. https://www.sciencedirect.com/science/article/pii/S1876619615002144

14. Juni Ekowati, Suko Hardjono, Iwan Sahrial Hamid. 2015. Ethyl p-methoxycinnamate from Kaempferia galangal inhibits angiogenesis through tyrosine kinase, Universa Medicina, 34(1),43-51. DOI: https://dx.doi.org/10.18051/UnivMed.2015.v34.43-51. https://univmed.org/ejurnal/index.php/medicina/article/view/49

15. Nuzul Wahyuning Diyah, Juni Ekowati, Siswandono. 2014. Synthesis and Antitumor Activity Evaluation of N,N’-dibenzoyl-N,N’-diethylurea against Human Breast Cancer Cell Line (MCF-7), IJPPS, 6(2), 315-318. https://innovareacademics.in/journal/ijpps/Vol6Issue2/8812.pdf

16. Marcellino Rudyanto, Juni Ekowati, Tri Widiandani, Toshio Honda. 2014. Synthesis and Brine Shrimp Lethality Test of Some Benzoxazine and Aminomethyl Derivatives of Eugenol. IJPPS, 6(2), 96-98. https://innovareacademics.in/journals/index.php/ijpps/article/view/4109

17. Juni Ekowati, Nur Chaulah, Tutuk Budiati. 2014. Sintesis dan Uji in silico Turunan Asam Fenilpropanoat sebagai Anti platelet. Berkala Ilmiah Kimia Farmasi, 3(2), 44-50. https://www.semanticscholar.org/paper/SINTESIS-DAN-UJI-IN-SILICO-TURUNAN-ASAM-SEBAGAI-Ekowati-Chaulah/de15f6fc97a7a43630777ce0697aba94a34ddcca.

18. Juni Ekowati & Nuzul Wahyuning Diyah.2013. Aktivitas Antinociceptive dan Uji In Silico terhadap Cyclooxygenase dari Asam p-metoksisinamat dan Asam m-metoksisinamat. Berkala Ilmiah Kimia Farmasi, 2(1), 33-40. https://pdfs.semanticscholar.org/91de/5779311fe63a7ec5e23f950f255c1d511299.pd

19. Juni Ekowati, Bimo A. Tedjo, Shigeru Sasaki, Kimio Highasiyama, Sukardiman, Siswandono, Tutuk Budiati. 2012. Structure Modification of Ethyl p-methoxycinnamate and Their Bioassay as Chemopreventive Agent Against Mice’s Fibrosarcoma, IJPPS, 3 (suppl.4), 528-532. https://pdfs.semanticscholar.org/0926/554e1b03b41914387f3b2d4512b6198b6d6b.pdf

20. Ethyl p-methoxy-cinnamate Isolated from Kaempferia galangal Inhibits Angiogenesis Through Interaction with Tyrosine Kinase, Jurnal Universa Medicina, Vol. 34, No.1, 2015

21. Pengaruh Substituen 2-Metoksi pada Sintesis Turunan 2- Hidroksi-benzohidrazida dengan Iradiasi Gelombang Mikro, Jurnal Berkala Ilmiah Kimia Farmasi (e-jurnal), Vol. 4, No. 2, 2015
22. Synthesis Ferulic Acid and Its Non Covalent Inclusion with Hydropropyl-ß-Cyclodextrin, Scentia Pharmacetica, 2015
23. Synthesis, Molecular Docking and Anticancer Activity test of Derivatives of p-Methoxycinnamoyl Hydrazyde, Bulletin of the Korean Chemical Society, 2015
24. Sintesis Khalkon dan Derivatnya menurut reaksi kondensasi Claisen Schmidt dengan iradiasi gelombang mikro, Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, Vol. 1, No. 1, 2014
25. Sistesis dan uji In Silico turunan Asam Fenil Propanoat sebagai Anti Platelet, Jurnal Berkala Ilmiah Kimia Farmasi, Vol. 3, No. 2, 2014
26. Synthesis and Brine Shrimp Lethality Test of Some Benzoxa-xine and Aminometil Deriva-tives, IJPPS, Vol. 6, Issue. 2, 2014
27. Synthesis and Antitumor Activity Evaluation of N,N’- dibenzoyl - N,N’-diethylurea Againts Human Breast Cancer Cell Line, IJPPS, Vol. 6, Issue. 2, 2014
28. Pengaruh gugus metoksi posisi orto(o) dan para(p) pada benzaldehida terhadap sintesis turunan khalkon dengan metode Kondensasi Aldol, Jurnal Berkala Ilmiah Kimia Farmasi, Vol. 2, No. 1, 2013
29. Aktivitas Antinociceptiv dan Uji In Silico terhadap Cyclooxygenase dari Asam p-metoksisinamat dan Asam mmetoksisinamat, Jurnal Berkala Ilmiah Kimia Farmasi, Vol. 2, No. 1, 2013
30. Achmad Syahrani, Juni Ekowati, 2019. Optimasi Kondisi Sintesis Asam 4-Benzoiloksisinamat Menggunakan Iradiasi Gelombang Mikro. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia (Vol. 6 No. 1)
31. Juni Ekowati, Marcellino Rudyanto, 2020. The Effect of Methyl and Chloro Substituent Compounds in Amida Derivatives Synthesis from p-Metoxicynamic Acid with Microwaves Irradiation. Berkala Ilmiah Kimia Farmasi (Vol. 7 No. 2)
32. The thermodynamic study of p-methoxycinnamic acid inclusion complex formation, using β-cyclodextrin and hydroxypropyl-β-cyclodextrin; Journal of Basic and Clinical Physiology and Pharmacology;  2021
33. Shallot skin profilling, computational evaluation of physicochemical properties, ADMET, and molecular docking of its components against P2Y12 receptor; Journal of Basic and Clinical Physiology and Pharmacology;  2021
34. In silico estrogen receptor alpha antagonist studies and toxicity prediction of Melia azedarach leaves bioactive ethyl acetate fraction; Journal of Advanced Pharmaceutical Technology and Research;  2021
35. In-silico INVESTIGATION OF FERULIC ACID DERIVATES AGAINST MAIN PROTEASE SARS-COV; Rasayan Journal of Chemistry;  2022
36. Efficacy of Probiotic on Duodenal TNF-α Expression and the Histological Findings in the Liver and Lung in Animal Model Canine Coronavirus; Pharmacognosy Journal;  2022
37. Juni Ekowati, 2022. Synthesis and Antiplatelet Activity of 4- Hidroxy-3-Methoxycinnamic Acid. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia (Vol. 9 No. 1).
38. Synthesis, anti-angiogenic activity and prediction toxicity of (E)-3-(3-methoxyphenyl) propenoic acid; Journal of Public Health in Africa;  2023
39. In silico study of phytochemicals contained in Brucea javanica in inhibiting the InhA enzyme as antituberculosis; Journal of Public Health in Africa;  2023
40. Chemoinformatics approach to design and develop vanillin analogs as COX-1 inhibitor; Journal of Public Health in Africa;  2023
41. In vivo anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol; Journal of Public Health in Africa;  2023
42. The dissolution of p-methoxycinnamic acid-?-cyclodextrin inclusion complex produced with microwave irradiation; Journal of Public Health in Africa;  2023

Contact

Prof. Dr. Juni Ekowati, M.Si.,Apt

E-mail j_ekowati@yahoo.com

E-mail Instansi juni-e@ff.unair.ac.id