Prof. Dr. Aty Widyawaruyanti, M.Si.,Apt

Profiles

• Sinta Profile
• Scopus Profile

Courses

Pharmaceutical Botany I, Practical Pharmaceutical Botany I, Pharmacognosy, Practical Pharmacognosy, Pharmaceutical Botany II, Practical Pharmaceutical Botany II, Pharmaceutical Manufactures I (PBL)

Research Interests

• Pharmacognosy and Phytochemistry
• Antinfective drugs discovery, espescially Antimalarial active compound/substances from plant and other natural products resource.

Selected Publications

1. Metabolite profile and in vitro cholinesterase inhibitory activity of extract and fractions of Aaptos suberitoides; Journal of Pharmacy and Pharmacognosy Research; 2023
2. The combination of Luvunga sarmentosa (BI.) and Eurycoma longifolia Jackhydro-alcoholic extract as a source of antioxidant and analgesic agent; Journal of Research in Pharmacy; 2023
3. Microscopic and physicochemical evaluation of Ruta angustifolia leaves; Journal of Public Health in Africa; 2023
4. Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents; F1000Research; 2023
5. Effect of geranylated dihydrochalcone from Artocarpus altilis leaves extract on Plasmodium falciparum ultrastructural changes and mitochondrial malate: Quinone oxidoreductase; International Journal for Parasitology: Drugs and Drug Resistance; 2023
6. Bioassay-guided fractionation and in vitro antiplasmodial activity of ethyl acetate fractions from Alectryon serratus (Sapindaceae) leaf; Tropical Journal of Pharmaceutical Research; 2022
7. In vitro acetylcholinesterase inhibitory activities of fractions and iso-agelasine C isolated from the marine sponge Agelas nakamurai; Journal of Research in Pharmacy; 2022
8. A tablet derived from Andrographis paniculata complements dihydroartemisinin-piperaquine treatment of malaria in pregnant mice; Journal of Basic and Clinical Physiology and Pharmacology; 2022
9. Evaluation of Antioxidant and Cholinesterase Inhibitory Activities of Various Extracts of Cassia spectabilis; Tropical Journal of Natural Product Research; 2022
10. Screening of Potential plants from Kalimantan as an Antimicrobial agent for Coliform bacteria; Research Journal of Pharmacy and Technology; 2022
11. The Active Marker compound identification of Artocarpus champeden Stembark extract, mora-chalkone A as antimalarial, Journal of Pharmacy and Pharmaceutical Sciences Vol 4, Suppl 5, 2012, 246-249, https://www.ijppsjournal.com/Vol4Suppl5/4886.pdf
12. Antiviral activities of Indonesian medicinal plants in the East Java region against hepatitis C virus, Virology Journal, 2013https://virologyj.biomedcentral.com/track/pdf/10.1186/1743-422X-10-259.
13. In vitro antimalarial activity screening of several Indonesia plants using HRP2 assay, Journal of Pharmacy and Pharmaceutical Sciences, 2014. https://www.ijppsjournal.com/Vol6Issue6/9306.pdf
14. In vivo antimalarial activity of Andrographis paniculatatablets, Procedia Chemistry, 2014. https://www.sciencedirect.com/science/article/pii/S1876619614002010
15. Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolialeaves, Fitoterapia, 2014.
16. The combination therapy model of Andrographis paniculataextract and chloroquine on Plasmodium bergheiinfected mice, Asian J Pharm Clin Res, 2015. https://www. innovareacademics.in/journals/index.php/ajpcr/article/download/2214/2160
17. Anti-malarial activity of isoquinolin alkaloids from the stem bark of Actinodaphne macrophylla,Natural Product Communications (NPC), 2015.
18. Antimalarial activity and toxicity of ethanol extract and fraction from Alectryon Serratus Leaves, International Journal of Pharmachy and Pharmaceutical Sciences, 2015. https://www.innovareacademics.in/journals/index.php/ijpps/article/download/5464/3445
19. Androghapolide determination of  Andrographis paniculataextract, ethyl acetate fraction and tablets by thin layer chromatography, Journal Chemical and Pharmaceutical Research, 2015. https://www.researchgate.net/publication/290899560_Andrographolide_determination_of_Andrographis_paniculata_extracts_ethyl_acetate_fractions_and_tablets_by_thin_layer_chromatography
20. Antimalarial Activity of Crude Extract of Artocarpus heterophyllus, Artocarpus altilis, and artocarpus camansi, Asian Journal of Pharmaceutical and Clinical Research, 2016. https://innovareacademics.in/journals/index.php/ajpcr/article/view/9248/3761
21. Antihepatitis C Virus Activity of Alectryon serratusleaves extract, Procedia Chemistry, 2016. https://ac.els-cdn.com/S1876619616000279/1-s2.0-S1876619616000279-main.pdf?_tid=6ab34995-3570-46fa-91d7-88e1421966bb&acdnat=1540872207_f64dd66c4c5d4ea8e27eb9fae301709d
22. Cytotoxic Effect of Crude Extrct nd Frction From Calotropis gigantea Leaves of Human Colon Cancer WIDR Cell Lines, International Journal of Phrmacy and Pharmceutical Sciences, 2017.
23. Preliminary study of safety and toxicity of cempedak capsules as an alternative complementary drug for malaria prophylaxis at Nanga Badau, Kalimantan, International Review of the armed forces medical services, 2017, 89, 4, 28-35,  https://www.researchgate.net/publication/315797918_Preliminary_Study_of_Safety_and_Toxicity_of_Cempedak_Capsules_as_an_Alternative_Complementary_Drug_for_Malaria_Prophylaxis_at_Nanga_Badau_Kalimantan
24. Antimalarial Activity And Survival Time Of Andrographis Paniculata Fraction (AS202-01) on Plasmodium berghei Infected Mice, Research Journal of Pharmaceutical, Biological and Chemical, 2017. https://www.rjpbcs.com/pdf/2017_8(1S)/[8].pdf
25. Antihepatitis C Virus activity of Indonesian mahogany (Toona sureni), Asian Journal of Pharmaceutical and Clinical Research, 2018. https://innovareacademics.in/journals/index.php/ajpcr/article/view/18126/13901
26. Effect of Andrographis paniculata tablet (AS201-01) on Transforming Growth Factor Beta (TGF-B) expression and parasite inhibition in mice placenta infected with Plasmodium berghei, Bali Medical Journal, 2018. https://www.balimedicaljournal.org/index.php/bmj/article/viewFile/785/1121
27. Calontropis gigantea leaf extract increases the efficacy of 5-fluorouracil and decrease the efficacy of doxorubicin in Widr colon cancer cell culture, Journal od applied pharmaceutical sciences, 2018. https://www.japsonline.com/admin/php/uploads/2599_pdf.pdf
28. Treated Plasmodium berghei infected pregnant mice by Andrographis paniculata tablet (AS201-01) decreasing the TLR-4 expression and apoptosis index of placental tissue, Journal od applied pharmaceutical sciences, 2018. https://japsonline.com/admin/php/uploads/2607_pdf.pdf
29. Bioanalytical method development and validation for qualification of morachalcone A in rabbit plasma using high performance liquid chromatography, Pakistan Jurnal of Pharmaceutical Science, 2018.https://www.pjps.pk/wp-content/uploads/pdfs/31/1/Supplementary/10-SUP-788.pdf
30. Alpha-mangostin effect on inhibition development stadium and globin accumulation against Plasmodium falciparum, Pharmacognosy Journal, 2018. https://phcogj.com/sites/default/files/PharmacognJ-10-783.pdf
31. Development of andrographolide – carboxymethyl chitosan nanoparticles: characterization, in vitro release and in vivo antimalarial activity study, Turkish Journal of Pharmaceutical Sciences, 2018. (https://cms.galenos.com.tr/Uploads/Article_19400/TJPS-15-136-En.pdf)
32. Antihepatitis C Virus Activity of Indonesian Mahogany (Toona Sureni), Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, issue 2, 2018, 87-90, https://innovareacademics.in/journals/index.php/ajpcr/article/view/18126/13901
33. Antiviral activities of Curcuma genus against hepatitis C virus, Natural Product Communication, 2018, vol 13, no.12, 1579-1582, https://www.researchgate.net/publication/330554027_Antiviral_Activities_of_Curcuma_Genus_against_Hepatitis_C_Virus.
34. In vitro antimalarial activity of chloroform, n-butanol, and ethyl acetate fractions of ethanol extract of Carthamus tinctorius Linn. Flower, Asian Journal of Pharmaceutical and Clinical Research, 2018, vol 11, issue 2, 121-123, https://innovareacademics.in/journals/index.php/ajpcr/article/view/15856
35. Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana, 2019, https://doi.org/10.1080/10286020.2018.1553958
36. Evaluation of a series of 9,10-anthraquinones as antiplasmodial agents, 2019. https://www.lettersindrugdesigndiscovery.com/articles/162871/evaluation-of-a-series-of-910-anthraquinones-as-antiplasmodial-agents
37. Antiviral activity of Phyllanthus niruri against hepatitis C virus, Malaysian Applied Biology July 2019, 48(3):105-111, https://www.researchgate.net/publication/334544795_ANTI-VIRAL_ACTIVITY_OF_Phyllanthus_niruri_AGAINST_HEPATITIS_C_VIRUS
38. Antiviral activity of Phyllanthus niruri against hepatitis C virus, Malaysian Applied Biology July 2019, 48(3):105-111, https://www.researchgate.net/publication/334544795_ANTI-VIRAL_ACTIVITY_OF_Phyllanthus_niruri_AGAINST_HEPATITIS_C_VIRUS
39. Mutiah, R., Widyawaruyanti, A., Sukardiman, S, 2017 , Ethyl Acetate Fraction Of Calotropis Gigantea Roots Induce Apoptosis Through Increased G2/M And Increased Expression Of Caspase-8 In Colon Cancer Widr Cell Line, Journal Of Applied Pharmaceutical Science, Volume 7, Issue 7, 1 July 2017, Pages 197-201
40. Hafid, A.F., Aoki-Utsubo, C., Permanasari, A.A., Adianti, M., Tumewu, L., Widyawaruyanti, A., Wahyuningsih, S.P.A., Wahyuni, T.S., Lusida, M.I., Soetjiptoa, Hotta, H Antiviral activity of the dichloromethane extracts from Artocarpus heterophyllus leaves against hepatitis C virus, Asian Pacific Journal of Tropical Biomedicine Volume 7, Issue 7, July 2017, Pages 633-639
41. Puspitasari, R., Wahyuni, T. S., Hafid, A. F., Permanasari, A. A., Tumewu, L., & Widyawaruyanti, A. (2022). Anti-Hepatitis C Virus Activity of Various Indonesian Plants from Balikpapan Botanical Garden, East Borneo. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 9(1), 48–54. https://doi.org/10.20473/jfiki.v9i12022.48-54
42. Bastiana, Widyawaruyanti, A., Ilmi, H., Tumewu, L., Prasetyo, B., Hafid, A. & Aryati (2022). A tablet derived from Andrographis paniculata complements dihydroartemisinin-piperaquine treatment of malaria in pregnant mice. Journal of Basic and Clinical Physiology and Pharmacology, 33(2), 175-183. https://doi.org/10.1515/jbcpp2020-0162
43. Wahyuni, T. S., Permatasari, A. A., Aoki-Utsubo, C., Widyawaruyanti, A., & Fuad, A. (2022). Anti-Hepatitis C Activity of Combination of Ruta angustifolia Extract and Ribavirin. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 9(2), 125–130. https://doi.org/10.20473/jfiki.v9i22022.125-130
44. Aristyawan, A. D., Setyaningtyas, V. F., Wahyuni, T. S., Widyawaruyanti, A., Ingkaninan, K., & Suciati, S. (2022). In vitro acetylcholinesterase inhibitory activities of fractions and iso-agelasine C isolated from the marine sponge Agelas nakamurai. Journal of Research in Pharmacy, 26(2), 279–286. https://doi.org/10.29228/jrp.126
45. Khasanah, U., Shalas, A. F., Resti, N. N., Nurdiana, M., & Widyawaruyanti, A. (2022). Bioassay-guided fractionation and in vitro antiplasmodial activity of ethyl acetate fractions from Alectryon serratus (Sapindaceae) leaf. Tropical Journal of Pharmaceutical Research, 21(1), 99–104. https://doi.org/10.4314/tjpr.v21i1.16

Contact

Prof. Dr. Aty Widyawaruyanti, M.Si.,Apt

E-mail aty_ww@yahoo.com

E-mail Instansi aty-w@ff.unair.ac.id