Junaidi Khotib, S.Si., M.Kes., Ph.D, Apt.


 

  Jenjang Pendidikan

No Jenjang Pendidikan Institusi Mulai Berakhir
1 Program Sarjana Airlangga University 1989 1994
2 Program Magister Airlangga University 1995 1998
3 Program Doktor Hoshi University 2001 2004

 

Riwayat Mengajar

No Subjek
1 Biologi Dasar
2 Biologi Molekular
3 Farmakologi Molekular
4 Farmakogenomik
5 Biofarmasetika Modern
6 Farmakometrik
7 Animal Modeling
8 Bioactivitas Multikomponen

 

Bidang Riset

No Subjek
1 Farmakologi Molekular
2 Bioekivalensi dan Biosimilaritas

 

Publikasi

No Publikasi Tahun
1 Narita, M., Mizoguchi, H., Khotib, J., Suzuki, M., Ozaki, S., Yajima, Y., Narita, M., Tseng, L.F. and Suzuki, T. (2002) Influence of a deletion of protein kinase C isoform in the G-protein activation mediated through opioid receptor-like-1 and -opioid receptors in the mouse pons/medulla. Neurosci. Lett. 331, 5-8. 2002
2 Narita, M., Khotib, J., Suzuki, M., Ozaki, S., Yajima, Y. and Suzuki, T. (2003) Heterologous -opioid receptor adaptation by repeated stimulation of -opioid receptor: up-regulation of G-protein activation and antinociception, J. Neurochem. 85, 1171-1179. 2003
3 Narita, M., Khotib, J., Suzuki, M., Ozaki, S., Yajima, Y., Mizoguchi, H., Tseng, L.F. and Suzuki, T. (2003) Direct evidence for the up-regulation of spinal -opioid receptor after repeated stimulation of -opioid receptors in the mouse. Eur. J. Neurosci. 18, 2498-2504. 2003
4 Khotib, J., Narita, M., Suzuki, M., Yajima, Y. and Suzuki, T. (2003) Studies on drug dependence (Rept. 381): Direct evidence for the up-regulation of central -opioid receptor functions induced by repeated stimulation of -opioid receptors. Japanese J. Neuropsycopharmacol. 23:318. 2003
5 Khotib, J., Narita, M., Suzuki, M., Yajima, Y. and Suzuki, T. (2004) Functional interaction among opioid receptor types: up-regulation of - and -opioid receptor functions after repeated stimulation of -opioid receptors. Neuropharmacology 46, 531-540. 2004
6 Ozaki, S., Narita, M., Narita, M., Ozaki, M., Khotib, J. and Suzuki, T. (2004) Role of extracellular signal-regulated kinase (ERK) in the ventral tegmental area (VTA) in the suppression of the morphine-induced rewarding effect in mice with sciatic nerve ligation. J. Neurochem. 88, 1389-1397. 2004
7 Khotib, J., Narita, M., Niikura, K., Yajima, Y. and Suzuki T. (2004) Studies on drug dependence (Rept. 387): Short-term Short-term up-regulation of -opioid receptor functions after repeated administration of -opioid receptor agonist (-)U-50,488H in the thalamus of rodents, J. Pharmacological Sci. 94(supp):227P 2004
8 Khotib, J., Narita, M., Niikura, K., Suzuki, M., Yajima, Y. and Suzuki T. (2005) Studies on drug dependence (Rept. 405): Involvement of neuronal migrating regulator in the development of tolerance to morphine-induced antinociception, J. Pharmacological Sci. 97(supp):96P 2005
9 Usui, A., Narita, M., Yajima, Y.., Khotib, J., Narita, M., and Suzuki T. (2005) Studies on pain control system (Rept. 34): A protease-activated receptor-1/platelet-derived growth factor pathway in spinal cord neurons in implicated in neuropathic pain after nerve injury, J. Pharmacological Sci. 97(supp):137P 2005
10 (10) Suzuki T, Nurrochmad A, Ozaki M, Khotib J, Nakamura A, Imai S, Shibasaki M, Yajima Y, Narita M (2005) Efect of a selective GABAB receptor agonist baclofen on the -opioid receptor agonist-induced antinociceptive, emetic and rewarding effects, Neuropharmacology 49: 1121-1131. 2005
11 Narita M, Nagumo Y, Shindo K, Narita M, Khotib J, Shibasaki M, Yanagisawa M, Nakamachi K, Shioda N, Suzuki T (2005) Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine, J Neurosci. 26(2):398-405. 2005
12 Narita M, Usui , Khotib J, Narita M, Nagumo Y, Niikura K, Suzuki M, Yajima Y, Suzuki T (2005) A protease-activated receptor-1/platelet-derived growth factor pathway in spinal cord neurons is implicated in neuropathic pain after nerve injury, J. Neurosci, 25 (43): 10000-10009 2005
13 Narita M, Kuzumaki N, Narita M, Kaneko C, Tamai E, Khotib J, Miyatake M, Shindo K, Nagumo Y, Tanaka S, Suzuki T. (2006) Age-related emotionality is associated with cortical delta-opioid receptor dysfunction-dependent astrogliosis. Neuroscience 137: 1359-1367. 2006
14 Hasmono D, Ariyanto AN, Khotib J., (2005) Role of a protein tyrosin phosphatase in the decreasing of blood glucose level in streptozotocin-induced diabetic mice. Airlangga Journal of Pharmacy 5 (2): 35-38 2005
15 (15) Khotib J., Irawati D., Pambudi P., Aryani T., (2006) The prospective of a typical dopamine antagonist in the attenuation of morphine-induced withdrawal syndrome. Airlangga Journal of Pharmacy 5 (2): 39-44 2006
16 Khotib, J., Narita, M., Narita, M., Niikura, K., Yajima, Y. and Suzuki T. (2012) Reversible up-regulation of -opioid receptor functions after repeated administration of -opioid receptor agonist (-)U-50,488H in the thalamus of rodents. Neuroscience, Submitted. 2012
17 Khotib J, Narita M, Narita M, Suzuki M, Niikura K, Kazuyuki I, Syamsiah S and Suzuki T (2012) Involvement of neuronal migrating regulator reelin in the development of tolerance to morphine-induced antinciception. J. Neurochem. Submitted 2012
18 Khotib et al (2014) Pharmaceutical interaction between cytostatic drugs and NaCl 0.9% and dextrose 5% infusion, Asian Journal of Pharmaceutical and Clinical Research 2014
19 Khotib et al (2014) The increasing of VEGF expression and re-epitelialization on dermal wound healing process after treatment of banana peel extract. International Journal of Pharmacy and Pharmaceutical Sciences 6 (11) : 427-430 2014
20 Khotib et al (2014) Biocompatible composite as gentamicin delivery system for osteomyelitis and bone regeneration. International Journal of Pharmacy and Pharmaceutical Sciences 6(3) : 223-226 2014
21 Khotib, J et al (2014) Pharmaceutical Interaction Between Cytostatic Drugs and NaCl 0.9% and Dextrose 5% Infusion 7 (Supl 2) : 116-119 2014
22 Khotib J et al (2015) The influence of sodium orthovanadate on p85 and gsk-3 expressions to the blood glucose regulation of type 2 diabetic mice (mus musculus) model, International Journal of Pharmacy and Pharmaceutical Sciences 7(1) : 115-119 2015

 

Keanggotaan Asosiasi

No Asosiasi
1 Ikatan Sarjana Farmasi Indonesia, 1996-2009
2 Ikatan Apoteker Indonesia, since 2009
3 Bioequivalence Working Group, since 2008
4 Asean Conference on Clinical Pharmacy, since 2007

 

Penghargaan

No Penghargaan Tahun
1 Best graduate of Faculty of Pharmacy Airlangga University 1993
2 Best graduate of Apothecary Program, Faculty of Pharmacy Airlangga University 1994
3 Post doctoral Fellow 2004
4 Visiting Lecture 2005
5 High Achievement Lecturer (1st rank) at Airlangga University 2009
6 Finalist of High Achievement Lecturer 2009

 

ACADEMIC & PROFESSIONAL SERVICES

2001-present: Lecturer at Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University, Surabaya, East Java, Indonesia.

2005-present: Visiting Lecture at Faculty of Pharmacy, International Islamic University Malaysia.

2007-present: Consultant of The National Agency of Drug and Food Control.

2007-present: Public Relation of Indonesia Bioequivalence Networking Group

2010-present : Expert Consultant of PT Bernopharm

2013-present : Expert Consultant of Daewoong – Infion Pharmaceutical Industry

 

RESEARCH EXPERIENCES

(1). Quality assurance of mefenamic acid 500 mg tablet in market, Young Researcher Grant, 1999/2000

(2). Quality assurance of combination sulphametoxazole and trimetophrim 400/80 mg in market, Young Researcher Grant, 1999/2000

(3). Effectiveness of an antidiabetic vanadyl sulphate in the lowering glucose concentration diabetic-mice, DIP A PNBP, 2005

(4). Involvement of tyrosin kinase in the development of tolerance to opioid-induced antinciception DIP A PNBP, 2005

(5) Antinociceptive effect of GABA agonist gabapentine in the neuropathic pain treatment in animal model, DIP A PNBP Unair, 2005

(6). Bioavailability and bioekivalence of risendronate 35 mg tablet, Kalbe Farma, 2005

(7) Mekanisme molekuler efek analgesik selektif agonis reseptor opioid kappa (-)U50,488H, DIPA PNBP Unair, 2005

(8) Bioavailability and bioequivalence of levofloxacine 500 mg tablet, Kimia Farma, 2006

(9) Cancer Model, BPPT, 2007-2009

(10) Prospek vanadium sebagai antidiabetik oral yang poten melalui penghambatan aktivitas tirosin kinase, Hibah Bersaing, 2008

(11) Peran Neuronal Migrating Factor pada Perkembangan Toleransi Analgesik, Strategis Nasional, 2009

(12) Regenerasi Sel Beta Pankreas Melalui Penghambatan Phosphatase Sebagai Upaya Mendapatkan Strategi Terapi Kausatif Pada Diabetes Mellitus, Penelitian Unggulan, 2010-2012

(13) Pharmaceutical Interaction sitostatika dalam cairan infus dasar, PT Widatra Bhakti, 2012

(14) Pengujian efek iritasi pada penggunaan vitamin C merk X, PT Bernofarm, 2013

(15) Evaluasi Adverse Event penggunaan HES pada fungsi hemodinamik, hepar dan ginjal, PT Widatra Bhakti, 2014-2015

(16) Regulasi Apoptosis dan Regenerasi Sel Beta Pankreas Sebagai Upaya Mendapatkan Strategi Terapi Kausatif Pada Diabetes Mellitus, Kemeterian Riset Teknologi dan Pendidikan Tinggi, 2015

(17) Erythropoeitin Study, Daewoong Foundation, 2015-2016

 

SEMINAR

(1). Khotib, J., Narita, M., Ozaki, S., Suzuki, T. Heterologous mu-receptor modification by repeated stimulation of kappa-receptor in the mouse brain. 33 rdInternational Narcotics Research Conference, California, July 9-14, 2002.

(2). Shimamura, M., Narita, M., Yajima, Y., Khotib, J., Kubota, C., Suzuki, T. Up-regulation of PGE 2-receptor, but not PGI 2- and opioid-receptors, in the mouse spinal cord following peripheral inflammation. 33 rdInternational Narcotics Research Conference, California, July 9-14, 2002.

(3). Khotib, J., Narita, M., Suzuki, M., Ozaki, S., Suzuki, T. Heterologous m-opioid receptor modification by repeated stimulation of k-opioid receptor: Up-regulation of G-protein activation and antinociception. The 23 rdJapan Narcotics Research Conference, Tokyo, August 23-24, 2002.

(4). Shimamura, M., Narita, M., Yajima, Y., Khotib, J., Kubota, C., Suzuki, T. Role of spinal COX/PG pathway in the expression of chronic inflammatory pain. 123 rdThe Japanese Pharmaceutical Society Meeting, Nagasaki, March 27-29, 2003.

(5). Khotib, J., Narita, M., Mizoguchi, H., Suzuki, M.,Yajima, Y., Tseng, L.F., Suzuki, T. The up-regulation of central mu-opioid receptors functions induced by repeated stimulation of kappa-opioid receptor. 34 thInternational Narcotics Research Conference, Perpignan, France, July 11-16, 2003.

(6). Kuzumaki, N., Narita, M., Khotib, J., Kaneko. C., Miyagawa, K., Tanaka, S., Suzuki, T. Mechanism of anxiogenic effect in normal aging. 1 stInternational Neurobehavioral Pharmacology Meeting, Okayama, September 12-15, 2003.

(7). Kuzumaki, N., Narita, M., Kaneko. C., Khotib, J., Tanaka, S., Suzuki, T. Mechanism of anxiogenic effect in normal aging. 109 thKanto Area Meeting of The Japanese Pharmacological Society, Tokyo, October 4, 2003.

(8). Khotib, J., Narita, M., Suzuki, M.,Yajima, Suzuki, T. Direct evidence for the up-regulation of central mu-opioid receptor functions induced by repeated stimulation of kappa-opioid receptor. 33 thJapan Neuropsycopharmacology Meeting, Nara, October 8-10, 2003.

(9). Khotib, J., Narita, M., Niikura, K., Yajima, Suzuki, T. Studies on drug dependence (Rept. 387): Short-term up-regulation of m-opioid receptor functions after repeated administration of the k-opioid receptor agonist in the thalamus of rodents. The 77 thAnnual Meeting of the Japanese Pharmacological Society, Osaka, Maret 8-10, 2004.

(10). Khotib, J., Narita, M., Niikura, K., Yajima Y., Syamsiah, S., Suzuki, T. Short-termed up-regulation of mu-opioid receptor functions after repeated administration of the kappa-opioid receptor agonist in the rodent. 35 thInternational Narcotics Research Conference, Kyoto, Japan, July 18-23, 2004.

(11). Khotib J., Narita M., Narita M., Suzuki M., Niikura K., Yajima Y., Syamsiah S and Suzuki. Studies on drug dependence (Rept. 405): Involvement of neuronal migrating regulator in the development of tolerance to morphine-induced antinciception. The 78 thAnnual Meeting of the Japanese Pharmacological Society, Yokohama, Maret 22-24, 2005.

(12). Usui A., Narita M., Yajima Y., Narita M., Khotib J., Suzuki T. Studies on pain control system (Rept. 34): Involvement of spinal thrombin/platelet-derived growth factor (PDGF) pathway in the development of neuropathic pain-like state. The 78 thAnnual Meeting of the Japanese Pharmacological Society, Yokohama, Maret 22-24, 2005.

(13). Rahmadi M., Khotib J., Suprapti B., Sjamsiah S. Antinociceptive effect of kappa-opioid receptor agonist in the acute and chronic-pain state. The 14 thAnnual Meeting of the Indonesia Pharmacy Association, Bali, June 17-19, 2005.

(14). Khotib J. Molecular mechanisms of development opioid-induced antinociceptive tolerance. The 14 thAnnual Meeting of the Indonesia Pharmacy Association, Bali, June 17-19, 2005.

(15). Khotib J., Zulkarnain BS., Yulistiani, Sjamsiah S., Suzuki T. Role of kappa opioid receptor agonist (-)U-50,488H on the attenuation of withdrawal symptoms in morphine or amphetamine induced-dependence. The 14 thAnnual Meeting of the Indonesia Pharmacy Association, Bali, June 17-19, 2005.

(16). Khotib J., Zulkarnain BS., Analgetics. National Seminar and Pharmacotherapy Update, Surabaya, January 16-17, 2007

(17). Khotib J, Kusumawati I., Rahmadi M., Zulkarnain BS., Dyatmiko W., Supraspinal antinociceptive activity of ethanol extract of Kaemferia galangaLinn rhizomes and Sida rhombifoliaL herbs. The IOCD International Symposium, Surabaya, April 8-11, 2007

(18). Khotib J, Budiatin AS, The effectiveness of a diseased-animal model for study of drug potency in the pathology-like state, Kongres Ilmiah XV ISFI, Jakarta, June 17-19, 2007

(19). Khotib J, Aryani T, Samirah, Molecular mechanism of a selective kappa opioid receptor agonist on the attenuation of morphine-induced withdrawal syndrome, Kongres Ilmiah XV ISFI, Jakarta, June 17-19, 2007

(20). Khotib J, Yulistiani, Dimas F, Asih D, Martiniani E, Semedi J and Syamsiah S. Drug utilization study in hospitalized patients with pulmonary tuberculosis at the state hospital in Surabaya, The 7th ASEAN Conference on Clinical Pharmacy, Shanghai, July 6-9, 2007

(21). Khotib J, Narita M, Aryani T, Syamsiah S and Suzuki T, Molecular mechanism of development of morphine-induced antinociceptive tolerance, , The 7th ASEAN Conference on Clinical Pharmacy, Shanghai, July 6-9, 2007

(22). Jayaputra V, Khotib J, Involvement of Mitogen Activated Protein (MAP) Kinase in the Development of Neuropathic Pain-Like State, USM-UNAIR First Collaborative Conference, Penang, 13-14 June 2007

(23). Apryani E, Khotib J, Pivotal Role reelin Signaling Pathway in the Development of Tolerance to Morphine Induced Antinociception, USM-UNAIR First Collaborative Conference, Penang, 13-14 June 2007

(24). Khotib J, Inactivation of protein Tyrosine Phosphatase (PTP-ase) linked Insulin Receptor Mediated the Hypoglycemic Effect of Vanadyl Sulfate, The 8th  Asian Conference on Clinical Pharmacy, Surabaya, 1-4 July 2008.

(25). Khotib J, Drug Utilization Study of Hospitalized Patient with Colorectal Cancer, USM-UNAIR First Collaborative Conference, Surabaya, 10-11 February 2009

(26) Khotib J, Involvement of Reelin in the Development of Neurophatic Pain, Joint Meeting 3 rdConggress Association of Shoutheast Asean Pain Society and Neuropathic Pain Special Interest Group, Bali, 17-20 April 2009

(27). Khotib J, The Role of Pharmacist in the Management of Chronic Pain in the Degenerative Disease, The 9th  Asian Conference on Clinical Pharmacy, Seoul, 26-30 September 2009

(28). Khotib J, The Rationality of Antineoplastics Therapy, The 10th  Asian Conference on Clinical Pharmacy, Singapura, 9-12 July 2010.

(29). Khotib J, The Pharmacy Education in Indonesia, 11st  Asian Conference on Clinical Pharmacy, Manila, 24-27 June 2011.

 

Contact

Phone  : +62-31 591 5552 | +62-31 593 9934
Management Office of Airlangga University Kampus C Mulyorejo,
Surabaya 60115 Surabaya Indonesia 

 


Agenda
Unduhan