Assoc. Prof. Kornkanok Ingkaninan

Name: Kornkanok Ingkaninan

Dates to birth: 19 June 1967

Place of Birth: Bangkok

Nationality: Thai

Position: Associate Professor

Professional Address:

Bioscreening Unit, Department of Pharmaceutical Chemistry and Pharmacognosy

Faculty of Pharmaceutical Sciences, Naresuan University

Phitsanulok 65000, Thailand

Tel. 66-81-4817350  Fax 66-55-261057

Email: k_ingkaninan@yahoo.com, kornkanoki@hotmail.com

 

Education

-2000: PhD from Division of Pharmacognosy, Leiden University, The Netherlands

-1994: MPharm (Pharmacognosy) fromChulalongkorn University, Thailand

-1990: BPharm. fromChulalongkorn University, Thailand

 

Academic Position

-Associate Professor of Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University

 

Professional Career

-Faculty member at Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand

Lecturer: June 1995 – February 2002

Assistant professor: February 2002 - April 2004

Associate Professor: April 2005 - now

Research Areas of Interest:

-Lead finding from natural sources such as AChE inhibitors, PDE-5 inhibitors, antioxidant and antiandrogen

-Phytochemical analysis and quality control of herbal medicines

-Method development for the rapid isolation and identification of active compounds

 

Publications

  1. Ingkaninan, K., Hermans-Lokkerbol, A.C.J., and Verpoorte.R. (1999): Comparison of some centrifugal partition chromatography systems for a general separation of plant extracts. J. Liq. Chrom. & Rel. Technol., 22:885-896.
  2. Ingkaninan, K., von Frijtag Drabbe Künzel, J.K., IJzerman, A.P., and Verpoorte, R. (1999): Interference of fatty acid fraction in some receptor binding assays. J. Nat. Prod., 62:912-914.
  3. Ingkaninan, K.,IJzerman, A.P., Taesotikul, T., and Verpoorte, R. (1999): Isolation of opioid active compounds from Tabernaemontanapachysiphonleaves. J. Pharm. Pharmacol., 51:1441-1446.
  4. Ingkaninan, K., IJzerman, A.P., and Verpoorte, R. (2000): Luteolin, a compound with adenosine A 1receptor binding activity and chromone and dihydronaphthalenone constituents from Senna siamea. J. Nat. Prod., 63:315-7.
  5. Ingkaninan, K., de Best, C.M., Irth, H., van der Heijden, R., Hofte, A.J.P., Karabatak, B., Tjaden, U.R., van der Greef, J., and Verpoorte, R. (2000): High performance liquid chromatography with on-line coupled UV-mass spectrophotometric-biochemical detection for identification of acetyl cholinesterase inhibitors from natural products . J. Chromatogr. A, 872:61-73.
  6. Ingkaninan, K.,Hazekamp, A., Hoek, A.C., Balconi, S., and Verpoorte, R. (2000): Application of a centrifugal partition chromatography in a general separation and dereplication procedure for plant extracts. J. Liq. Chrom. & Rel. Technol., 23:2195-2208.
  7. Ingkaninan, K.,Hazekamp, A., de Best, C.M., Irth, H., Tjaden, U.R., van der Heijden, R., van der Greef, J., and Verpoorte, R. (2000): The application of HPLC with on-line coupled UV-MS-biochemical detection for an acetylcholinesterase inhibitor from Narcissus'Sir Winston Churchill'. J. Nat. Prod., 63:803-806.
  8. In Kyung Rhee, van de Meent, M., Ingkaninan, K. & Verpoorte, V. (2001)Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining J. Chromatogr A., 915:217-223.
  9. Ingkaninan, K,. Yuyaem, T., Thongnoi, W. (2001): Anti-cholinesterase Activity in Stephania venosaSpreng. Naresuan University Journal, 9: 35-40.
  10. Ingkaninan, K., Irth, H. & Verpoorte, V. (2002) Screening of Amaryllidaceae for biological activities: acetylcholinesterase inhibitors in Narcissus. In : Hanks, G. R. editor . Narcissus and daffodil; the genus Narcissus. Taylor & Francis, London. 369-379.
  11. Verpoorte, R., Ingkaninan, K. and van der Heijden, R. (2002) New perspectives for plant secondary metabolite production. Proceedings of the PSE.Kluwer Academic Publisher.
  12. Saiin, C., Rattanajak, R., Kamchonwongpaisan, S., Ingkanninan, K.,Sukontason, K., Buramee, A., and Sirithunyalug, B. (2003): Isolation and in vitroantimalarial activity of hexane extract from Thai Picrasma javanicaBL stembark. Southeast Asian J Trop Med Public Health, 34 (suppl 2):1-5.
  13. Ingkaninan, K.Temkitthawon, P., Chuenchom, K., Yuyaem, T., Thongnoi, W. (2003): Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies. J. Ethonopharmacol. 89: 261-264.
  14. Nuengchamnong, N., Hermans-Lokkerbol, A.J.C. and Ingkaninan, K. (2004) Separation and detection of the antioxidant flavonoids, rutin and quercetin, using HPLC coupled with colorimetric detection of antioxidant activity . Naresuan University Journal12: 25-37.
  15. Nuengchamnong, N., de Jong, C.F., Bruyneel, B., Niessen W.M.A., Ingkaninan, K., Irth I (2005) HPLC on-line coupled to Mass spectrometry and bioactivity for screening the radical scavenger compounds in Butea superbaRoxb. Phytochem. Anal.16: 422-428.
  16. Nuengchamnong, N., Ingkaninan, K.(2005) Evaluation of antioxidant activity in Thai herbal beverage and wine. FDA journal2:65-70.
  17. Thanabhorn, S., Jaijoy, K., Thamaree, S., Ingkaninan, K.and Panthong, A. (2005) Acute and subacute toxicity study of the ethanol extract from Alternanthera philoxeroidesGriseb. Mahidol University Journal of Pharmaceutical Sciences. 32:7-14.
  18. Thanabhorn, S., Jaijoy, K., Thamaree, S., Ingkaninan, K.and Panthong, A. (2005) Acute and subacute toxicity study of the ethanol extract from Cyperus rotundus Linn. Mahidol University Journal of Pharmaceutical Sciences. 32:370-373.
  19. Markmee, S., Ruchirawat, S., Prachyawarakorn, V, Ingkaninan, K., Khorana, N. (2006) Isoquinoline Derivatives as Potential Acetylcholinesterase Inhibitors. Bioorg. Med. Chem. Lett.,16: 2170-2172 .
  20. Ingkaninan, K, Phengpa, P., Yuenyongsawad, S., Khorana, N. (2006) Acetylcholinesterase inhibitors from Stephania venosaTuber . J. Pharm. Pharmacol., 58:695-700.
  21. Ingkaninan, K., Changwijita, K., Suwanborirux, K. (2006) Vobasinyl-Iboga Bisindole Alkaloids, Potent Acetylcholinesterase Inhibitors from Tabernaemontana divaricataroot. J. Pharm. Pharmacol.58: 847-852.
  22. Thanabhorn, S., Jaijoy, K., Thamaree, S., Ingkaninan, K.and Panthong, A. (2006) Acute and subacute toxicity study of the ethanol extract from Lonicera japonicaThunb. J. Ethonopharmacol. 107:370-373.
  23. Thanabhorn, S., Jaijoy, K., Thamaree, S., Ingkaninan, K.and Panthong, A. (2006) Acute and subacute toxicity study of the ethanol extract from the fruits of Terminalia belerica. Mahidol University J Pharm Sci.33: 23-30.
  24. Sriprang, S., Khorana, N. and Ingkaninan, K.(2006) Acetylcholinesterase Inhibitor from Stephania suberosaForman. NU Science Journal3: 1-11.
  25. Chattipakorn, S., Pongpanparadorn, A., Pratchayasakul, W., Pongchaidacha, A., Ingkaninan, K.and Chattipakorn, N. (2007) Tabernaemontana divaricataExtract Inhibits Neuronal Acetylcholinesterase Activity in Rats. J. Ethonopharmacol. 110:61-68.
  26. Phrompittayarat, W., Putalun, W., Tanaka, H., Wittaya-areekul, S., Jetiyanon, K., and Ingkaninan, K.(2007) An enzyme-linked immunosorbant assay using polyclonal antibodies against bacopaside I. Anal. Chim. Acta.584:1-6.
  27. Phrompittayarat, W., Putalun, W., Tanaka, H., Wittaya-areekul, S., Jetiyanon, K., and Ingkaninan, K.(2007) Determination of pseudojujubogenin glycosides from Brahmi based on immunoassay using a monoclonal antibody against bacopaside I. Phytochem. Anal.18: 411-418.
  28. Nuengchamnong, N., Ingkaninan, K., Kaewruang, W., Wongareonwanakij, S., and Hongthongdaeng, B. (2007) Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal.15: 853-858.
  29. Phrompittayarat, W., Putalun, W., Tanaka, H., Jetiyanon, K., Wittaya-areekul, S., and Ingkaninan, K. (2007) Comparison of Various Extraction Methods of Bacopa monnieriNaresuan University Journal.15:29-34.
  30. Kamonwannasit, S., Putalun, W., Phrompittayarat, W. Ingkaninan, K., Tanaka, H. (2007) Production of Pseudojujubogenin from callus cultures of Bacopa monnieri(L.) Wettst . IJPS.3: 53-59.
  31. Langjae, R, Bussarawit, S, Yuenyongsawad, S, Ingkaninan, K, Plubrukarn, A. (2007) Acetylcholinesterase-inhibiting steroidal alkaloid from the sponge Corticiumsp. St eroids.72: 682-685.
  32. Phrompittayarat, W., Wittaya-areekul, S., Jetiyanon, K., Putalun, W., Tanaka, H., and Ingkaninan, K.(2007) Determination of saponin glycosides in Bacopa monnieri by reversed phase high performance liquid chromatography. Srinakharinwirot Journal of Pharmaceutical Sciences.2: 26-32.
  33. Boriwanwattanarak, P., Ingkaninan, K., Khorana, N., Viyoch,J. (2008) Development of curcuminoids hydrogel patch using chitosan from various sources as controlled-release matrix. Int. J. Cosmet. Sci.30(3):205-218.
  34. Nukoolkarn, V.S., Saen-oon, S., Rungrotmongkol, T., Hannongbua, S., Ingkaninan, K., Suwanborirux K. (2008) Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosian. sp. Bioorg Med Chem.16(13):6560-6567.
  35. Temkitthawon, P., Viyoch, J., Limpeanchob, N., Pongamornkul, W., Sirikul, C., Kumpila, A., Suwanborirux, K., Ingkaninan K.(2008) Screening for phosphodiesterse inhibitory activity of Thai medicinal plants . J. Ethnopharmacol.119, (2): 214-217.
  36. Phrompittayarat, W., Wittaya-areekul,S., Jetiyanon, K.,Putalun, W., Tanaka, H., and Ingkaninan, K.(2008) Stability studies of saponins in B acopa monnieridried ethanolic extracts. Planta Med.74:1756-1763.
  37. Yoysungnoen, P., Kantasa, P., Ingkaninan, K.(2008) Cardiovasculareffects of Tabernaemontana divaricataroot extract in anesthetized rats. TJPS.21: 2-7.
  38. Sangnoi, Y, Sakulkeo, O, Yuenyongsawad, S, Kanjana-opas, A, Ingkaninan K,Plubrukarn, A, Suwanborirux, K. (2008) Acetylcholinesterase-inhibiting activity of pyrrole derivatives from a novel marine gliding bacterium, Rapidithrix thailandica. Mar Drugs.578-586.
  39. Tiyaboonchai, W., Srisopa, P., Viyoch, J., Ingkaninan, K. (2008) Solid lipid microparticles as a delivery carrier for turmeric crude extract containing curcuminoids. Naresuan University Journal, 16: 43-45.
  40. Limpeanchob,N., Jaipan, S., Rattanakaruna, S., Phrompittayarat,W., Ingkaninan , K. (2008) Neuroprotective Effect of Bacopa monnierion beta-amyloid-induced cell death in primary cortical culture. J. Ethnopharmacol.120:112-117.
  41. Saraphanchotiwitthaya, A., Ingkaninan, K., Sripalakit, P. (2008) Effect of Bacopa monnieraLinn. extract on murine immune response in vitro. Phytother Res.22:1330-1335.
  42. Kamonwannasit, S., Phrompittayarat, W., Ingkaninan, K.,Tanaka, H., Putalun, W. (2008) Improvement of pseudojujubogenin glycosides production from regenerated Bacopa monnieri(L.) Wettst. and enhanced yield by elicitors. Z Naturforsch C.63 (11-12): 879-883.
  43. Nuengchamnong, N., Ingkaninan, K.(2009) On-line Characterization of phenolic antioxidants in fruit wines from family myrtaceae by liquid chromatography combined with electrospray ionization tandem mass spectrometry and radical scavenging detection. LWT - Food Sci. Technol.42, (1): 297-302.
  44. Khorana, N., Markmee, S., Ingkaninan, K., Ruchirawat, S., Kitbunnadaj, R, Pullagurla, M.R.(2009) Evaluation of a new lead for acetylcholinesterase inhibition. Med. Chem. Res.18:231–241.
  45. Imsungnoen, N, Phrompittayarat, W, Ingkaninan K,Tanaka, H, Putalun, W.(2009) Immunochromatographic assay for the detection of pseudojujubogenin glycosides. Phytochem Anal.20:64-67.
  46. Murebwayire, S, Ingkaninan, K,Changwijit, K, Frédérich, M, Duez, P. (2009) Triclisia sacleuxii(Pierre) Diels (Menispermaceae), a potential source of acetylcholinesterase inhibitors. J Pharm Pharmacol.61:103-107.
  47. Nuengchamnong, N., Krittasilp, K., Ingkaninan, K.(2009) Rapid screening and identification of antioxidants in aqueous extracts of Houttuynia cordatausing LC-ESI-MS coupled with DPPH assay. Food Chem.117: 750-756
  48. Rabintossaporn, P., Saenthaweesuk, S., Thuppia, A., Ingkaninan, K., Sireeratawong, S. (2009) The histological examination of livers in normaland streptozotocin-induced diabetic rats received Annona squamosaL. aqueous leaves extract. Thammasat Medical Journal. 9: 39-44.
  49. Rabintossaporn, P., Saenthaweesuk, S., Thuppia, A., Ingkaninan, K., Sireeratawong, S. (2009) Antihyperglycemic and histological effects on the pancreas of the aqueousleaves extract of Annona squamosaL. in normal and diabetic rats. Songklanakarin J. Sci. Technol31: 73-78.
  50. Hansakul, P., Ngamkitidechakul, C., Ingkaninan, K., and Panunto, W. (2009) Antiproliferative, apoptotic induction, and antiinvasive effects of Leersia hexandra(L.) Sw., Panicum repensLinn., and Brachiaria mutica(Forsk.) Stapf extracts on human cancer cells. Songklanakarin J. Sci. Technol.31: 79-84.
  51. Thuppia, A., Rabintossaporn, P., Saenthaweesuk, S., Ingkaninan, K.,Sireeratawong, S. (2009) Hypoglycemic effect of the water extract from leaves of Lagerstroemia speciosaL. in streptozotocin-induced diabetic rats. Songklanakarin J. Sci. Technol. 31: 133-137.
  52. Saenthaweesuk, S., Thuppia, A., Rabintossaporn, P., Ingkaninan, K.,Sireeratawong, S. (2009) The study of hypoglycemic effects of the Morus alba L. leave extract and histology of the pancreatic islet cells in diabetic and normal rats. Thammasat Medical Journal. 9: 33-40.
  53. Nuengchamnong, N., Ingkaninan, K.(2010) On-line HPLC-MS-DPPH assay for the analysis of phenolic antioxidant compounds in fruit wine: Antidesma thwaitesianumMuell.” Food Chem.118: 147-152
  54. Uabundit, N., Wattanathorn, J., Mucimapura, S., Ingkaninan, K. (2010) Cognitive enhancement and neuroprotective effects of Bacopa monnieriin Alzheimer's disease model, Ethnopharmacol .127: 26-31 .
  55. Tep-Areenan, P., Ingkaninan, K.and Randall,M.D. (2010). Mechanisms of Kaempferia parvifloraextract (KPE)-induced vasorelaxation in the rat aorta. Asian Biomed., 4: 103-111.
  56. Paibon, W., Yimnoi, C.A., Tembab, N., Boonlue, W., Jampachaisri, K., Nuengchamnong, N., Waranuch, N., Ingkaninan, K.(2010) Comparison and evaluation of volatile oils from three different extraction methods for some Thai fragrant flowers. Int J Cosmet Sci.23: 1-9.
  57. Duangjai, A., Ingkaninan, K., Limpeanchob, N. (2010) Potential mechanisms of hypocholesterolaemic effect of Thai spices/dietary extracts. Nat Prod Res.8:1-12.
  58. Nakdook, W., Khongsombat, O., Taepavarapruk, P., Taepavarapruk, N., Ingkaninan, K. (2010) The effects of Tabernaemontana divaricataroot extract on amyloid beta-peptide 25-35 peptides induced cognitive deficits in mice . J Ethnopharmacol.130:122-126.
  59. Fuangchan, A., Sonthisombat, P., Seubnukarn, T., Chanouan, R., Chotchaisuwat, P., Sirigulsatien, V., Ingkaninan, K., Plianbangchang, P., Haines, S. T. (2011) Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients. J Ethnopharmacol.134: 422-428.
  60. Malakul, W., Thirawarapan, S., Ingkaninan, K., Sawasdee, P. (2011) Effects of Kaempferia parvifloraWall. Ex Baker on endothelial dysfunction in streptozotocin-induced diabetic rats. J Ethnopharmacol.133: 371-377.
  61. Nuengchamnong, N., Krittasilp, K., Ingkaninan, K.(2011) Characterisation of phenolic antioxidants in aqueous extract of Orthosiphon grandiflorustea by LC–ESI-MS/MS coupled to DPPH assay. Food Chem.127: 1287-1293.
  62. Wisuttiprot, W., Somsiri, A., Ingkaninan, K., Waranuch, N. (2011) A novel technique for chitosan microparticle preparation using a water/silicone emulsion: green tea model. Int J Cosmet Sci.33: 351-358.
  63. Duangjai, A., Ingkaninan, K.,Limpeanchob, N. (2011) Potential mechanisms of hypocholesterolaemic effect of Thai spices/dietary extracts. Nat Prod Res. 25: 341-352.
  64. Wattanathorn, J., Jittiwat, J., Tongun, T., Muchimapura, S., Ingkaninan, K. (2011) Zingiber officinalemitigates brain damage and improves memory impairment in focal cerebral ischemic rat. Evid Based Complement Alternat Med2011:429505..
  65. Kongkaneramit, L., Witoonsaridsilp, W., Peungvicha, P., Ingkaninan, K., Waranuch, N., Sarisuta, N. (2011) Antioxidant activity and antiapoptotic effect of Asparagus racemosusroot extracts in human lung epithelial h460 cells. Experimental and Therapeutic Medicine. 2: 143-148.
  66. Tothiam, C., Phrompittayarat, W., Putalun, W., Tanaka, H., Sakamoto, S., Khan, I.A., Ingkaninan, K.(2011) An enzyme-linked immunosorbant assay using monoclonal antibody against Bacoside A3 Phytochem Anal. 22:385-391.
  67. Changwichit, K., Khorana, N., Suwanborirux, K., Waranuch, N., Limpeanchob, N., Wisuitiprot, W., Suphrom, N., Ingkaninan, K.(2011) Bisindole alkaloids and secoiridoids from Alstonia macrophyllaWall. ex G.Don Fitoterapia. 82: 798-804.
  68. Hematulin, A., Ingkaninan, K., Limpeanchop, N., Sagan, D. (2011) Derris scandensextract radiosensitizers HT-29 colon cancer cells. Siriraj Med J. 63:1-4.
  69. Kamkaew, N., Scholfield, C.N., Ingkaninan, K.,Maneesai, P., Parkington, H.C., Tare, M., Chootip, K. (2011) Bacopa monnieriand its constituents is hypotensive in anaesthetized rats and vasodilator in various artery types. J. Ethnopharmacol.137: 790-795.
  70. Malakul, W., Ingkaninan, K., Sawasdee, P., Woodman, O.L. (2011) The ethanolic extract of Kaempferia parviflorareduces ischaemic injury in rat isolated hearts. J. Ethnopharmacol.137: 184-191.
  71. Phrompittayarat, W., Jetiyanon, K.,Wittaya-areekul,S., Putalun, W., Tanaka, H., Khan, I., and Ingkaninan, K.(2011) Influence of seasons, different plant parts, and plant growth stages on saponin quantity and distribution in Bacopa monnieri. Songklanakarin J Sci Technol.32:193-199.
  72. Temkitthawon, P., Hinds, T.R., Beavo, J.A., Viyoch, J., Suwanborirux, K., Pongamornkul, W., Sawasdee, P., Ingkaninan, K.(2011) Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. (2011) J. Ethnopharmacol.137: 1437-1441
  73. Wisuitiprot, W., Somsiri, A., Ingkaninan, K.,Waranuch, N. (2011) In vitrohuman skin permeation and cutaneous metabolism of catechins from green tea extract and green tea extract-loaded chitosan microparticles. Int J Cosmet Sci.33: 572-579.
  74. Pumthong, G., Asawanonda, P., Varothai, S., Jariyasethavong, V., Triwongwaranat, D., Suthipinittharm, P., Ingkaninan, K.,Leelapornpisit, P., Waranuch, N. (2011) Curcuma aeruginosa, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study. J Dermatolog Treat. 23: 385-392.
  75. Changwong, N., Sabphon, C., Ingkaninan ,K.,Sawasdee, P. (2012) Acetyl- and butyryl-cholinesterase inhibitory activities of mansorins and mansonones. Phytother Res. 26 : 392-396.
  76. Suphrom, N., Pumthong, G., Khorana, N., Waranuch, N., Limpeanchob, N., Ingkaninan, K. (2012) Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb. Fitoterapia.83 : 864-871.
  77. Khorana, N., Changwichit, K., Ingkaninan, K.,Utsintong, M. (2012) Prospective acetylcholinesterase inhibitory activity of indole and its analogs. Bioorganic & Medicinal Chemistry Letters, 15 : 2885-2888.
  78. Hematulin A., Meethang S., Ingkaninan K., Sagan D. (2012) Derris scandensBenth Extract Potentiates Radioresistance of Hep-2 Laryngeal Cancer Cells. Asian Pac J Cancer Prev. 13:1289-1295.
  79. Boonsom T., Waranuch N., Ingkaninan K.,Denduangboripant J., Sukrong S. (2012) Molecular analysis of the genus Asparagusbased on matK sequences and its application to identify A. racemosus, a medicinally phytoestrogenic species. Fitoterapia.83:947-953.
  80. Itsarasook, K., Ingkaninan, K.,Chulasiri, M., Viyoch, J. (2012) Antioxidant activity and cytotoxicity to human skin fibroblasts of Terminalia chebulafruit extract. International proceedings of Chemical, Biological & Environmetal Engineering: Biological and Life Sciences. 40: 43-46.
  81. Viyoch, J., Mahingsa, K., Ingkaninan, K. (2012) Effects of Thai Musa species on prevention of UVB-induced skin damage in mice. Food Chem Tox. 50 : 4292-4301.
  82. Peth-Nui T., Wattanathorn J., Muchimapura S., Tong-Un T., Piyavhatkul N., Rangseekajee P., Ingkaninan K., Vittaya-Areekul S. (2012) Effects of 12-week Bacopa monniericonsumption on attention, cognitive processing, working memory, and functions of both cholinergic and monoaminergic systems in healthy elderly volunteers. Evid Based Complement Alternat Med.2012;2012:606424. doi: 10.1155/2012/606424. Epub 2012 Dec 18.
  83. Ternchoocheep K., Ingkaninan K., Yasothornsrikul S. (2012) Tau protein attenuation ability of Bacopa monnieriextract on nerve growth factor-deprived PC12 cells in normal-serum and serum-free medium. Chiang Mai Med. J. 5159-69.
  84. Duangjai A., Ingkaninan K.,Praputbut S., Limpeanchob N. (2013) Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins. J Nat Med.37 : 303-310.
  85. Kamkaew N., Scholfield N.C., Ingkaninan K., Taepavarapruk N., Chootip K. (2013) Bacopa monnieriincreases cerebral blood flow in rat independent of blood pressure. Phytother Res. 27 : 135-138.
  86. Chaiyana, W., Schripsema, J, Ingkaninan, K., Okonogi, S. (2013) 3′-R/S-Hydroxyvoacamine, a potent acetylcholinesterase inhibitor from Tabernaemontana divaricata.Phytomedicine.20 : 543-548.
  87. Wattanathorn J., Muchimapura S., Thukham-Mee W., Ingkaninan K.,and Wittaya-Areekul S. (2014) Mangifera indicafruit extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in animal model of mild cognitive impairment. Oxid Med Cell Longev.2014;2014:132097. doi: 10.1155/2014/132097. Epub 2014 Jan 29.
  88. Onlom C., Khanthawong S., Waranuch N., Ingkaninan K .(2014) In vitroanti-malassezia activity and potential use in anti-dandruff formulation of Asparagus racemosus. Int J Cosmet Sci. 36, 74-78.
  89. 89. Suphrom, N., Srivilai, J., Pumthong, G., Khorana, N., Waranuch, N., Limpeanchob, N., Ingkaninan, K. (2014) Stability studies of anti-androgenic compounds in Curcuma aeruginosaextract. J. Pharm. Pharmacol .66 :1282-1293.
  90. 90. Srivilai, J., Khorana, N., Waranuch, N., Suphrom, N., Ingkaninan, K. (2014) Conformational analysis of an anti-androgenic, ( E,E)-8-hydroxygermacrene B, using NOESY and dynamic NMR spectroscopy. Med. Chem. Lett .24 : 3526-3529.
  91. Itsarasook, K., Ingkaninan, K., Viyoch, J. (2014) Artocarpin-enriched extract reverses collagen metabolism in UV-exposed fibroblasts. Biologia. 69: 943-951.
  92. Hematulin A., Ingkaninan K, Limpeanchob N, Sagan D. (2014) Ethanolic extract from Derris scandensBenth mediates radiosensitzation via two distinct modes of cell death in human colon cancer HT-29 cells. Asian Pac J Cancer Prev.15(4):1871-1877.
  93. Olatunji, O.J., Ogundajo, A.L.,Oladosu,I.A., Changwichit, K., Ingkaninan, K.,Yuenyongsawad, S., Plubrukarn, A. (2014)  Non-Competitive Inhibition of Acetylcholinesterase by Bromotyrosine Alkaloids. Nat. Prod. Commun.9: 1559-1561.
  94. Saraphanchotiwitthaya, A., Ingkaninan, K.(2014) Immunomodulatory activity of an acetone extract of terminalia bellerica roxb fruit on the mouse immune response in vitro. International Journal of Pharmacy and Pharmaceutical Sciences. 6(11):274-278.
  95. 95. Kruangtip, O., Chootip, K., Temkitthawon, P.; Changwichit, K.; Chuprajob, T.; Changtam, C., Suksamrarn, A., Khorana, N., Scholdfield, C, Ingkaninan, K. (2015)Curcumin analogues inhibit phosphodiesterase-5 and dilate rat pulmonary arteries. Pharm. Pharmacol.67: 87-95.
  96. Sabphon, C., Temkitthawon, P., Ingkaninan, K.,Sawasdee, P. (2015) Phosphodiesterase inhibitory activity of the flavonoids and xanthones from Anaxagorea luzonensis. NPC. 10(2):301-303.
  97. Ingkaninan, K.,Limpeanchop, N., Wittaya-areekul, S., Chootip, K., Taepawarapruk, P., Taepawarapruk, N., Wattanathorn, J., Sireeratawong, S., Putalun, W., Phrompittayarat, W., Tanaka, H. (2015) Research and development of Brahmi, a medicinal plant for memory improvement. Chinese Journal of Pharmacology and Toxicology. 29 suppl 1. 13.
  98. Petcharat,K., Singh, M., Ingkaninan, K.,Attarat, J., Yasothornsrikul, S. Bacopa monnieriProtects SH-SY5Y Cells Against tert-Butyl Hydroperoxide-induced Cell Death via the ERK and PI3K Pathways. (2015) Siriraj Med J. 67:20-26.
  99. Rungsang, T; Tuntijarukorn, P; Ingkaninan, K;Viyoch, J. (2015) Stability and clinical effectiveness of emulsion containing Asparagus racemosusroot extract. Scienceasia. 41: 236-245.
  100. Sirimangkalakitti, N., Olatunji, O.J., Changwichit, K., Saesong, T.,Chamni, S., Chanvorachote, P., Ingkaninan, K.,Plubrukarn, A. andSuwanborirux, K. (2015) Bromotyrosine alkaloids with acetylcholinesterase inhibitoryactivity from the Thai sponge Acanthodendrillasp. Nat. Prod. Commun.11:1945-1949.
  101. 101.Sichaem, J., Ingkaninan, K., Tip-pyang, S. (2016) A novel pyrrole alkaloid from the fruit peels of Strychnos nux-blanda. Natural Product Research.22: 1-6.
  102. Ngamdokmai, N., Waranuch, N., Chootip, K.,Neungchamnong, N., Ingkaninan, K.(2016) HPLC-QTOF-MS method for quantitative determination of active compounds in an anti-cellulite herbal compress. Songklanakarin Journal of Science and Technology. In press.
  103. Nuengchamnong, N., Sookying, S., Ingkaninan, K. (2016) LC-ESI-QTOF-MS based screening and identification of isomeric jujubogenin and pseudojujubogenin aglycones in Bacopa monnieriextract. Journal of Pharmaceutical and Biomedical Analysis.129: 121-134.
  104. Nuengchamnong, N., Ingkaninan, K.(2016) An on-line LC-MS/ DPPH approach towards the quality control of antioxidative ingredients in Sahastara. Songklanakarin Journal of Science and Technology.39, 123-129.
  105. Sireeratawong, S., Jaijoy, K., Khonsung, P., Lertprasertsuk, N., Ingkaninan, K.(2016) Acute and chronic toxicities of Bacopa monnieriextract in Sprague-Dawley rats. BMC Complementary and Alternative Medicines.16 (1): 249-258.
  106. Srivilai, J., Khorana, N., Waranuch, N., Wisuitiprot, W., Suphrom, N., Suksamrarn, A. and Ingkaninan, K.(2016) Germacrene analogs are anti-androgenic on androgen-dependent cells. Natural Product Communications, 11 (9): 1225-1228.
  107. Srivilai, J., Rabgay, K., Khorana, N., Waranuch, N., Nuengchamnong, N., and Ingkaninan, K.(2016) A new label-free screen for steroid 5a-reductase inhibitors using LC-MS. Steroids,116: 67-75.
  108. Srivilai, J., Phimnuan, P., Jaisabai, J., Luangtoomma, N., Waranuch, N., Khorana, N., Wisuitiprot, W., Scholfield, C.N., Champachaisri, K., and Ingkaninan, K.(2017) Curcuma aeruginosa Roxb. essential oil slows hair-growth and lightens skin in axillae; a randomised, double blinded trial. Phytomedicines, 25: 29-38.
  109. Sookying, S., Pekthong, D., Oo-puthinan, S., Phrompittayarat, W., Putalun, W., Tanaka, H., Xing, J., Zhan, Z., Khoran, N., Nuengchamnong, N., Ingkaninan, K.(2017) Immunochromatographic determination of bacopaside I in biological samples, J. Chrom. B, 1040; 60–66.
  110. Onlom C., Neungchamnong, N., Phrompittayarat, W., Putalun, W., Waranuch N., Ingkaninan K.(2017) Quantification of Saponins in Asparagus racemosusby HPLC-Q-TOF-MS/MS. Nat. Prod. Commun.12 (1): 7-10.
  111. Temkitthawon, P., Changwichit, K., Khorana, N., Viyoch, J., Suwanborirux, K., Ingkaninan, K.(2017) Phenanthrenes from Eulophia macrobulbonas novel phosphodiesterase-5 inhibitors. Nat. Prod. Commun., 12 (1): 79-82.
  112. Onlom C., Yang, Y., Aisa, H.A., Waranuch N., Phrompittayarat, W., Putalun, W., Ingkaninan K.(2017) Preparative and Rapid Purification of Saponins from Asparagus racemosusRoot by High Performance Centrifugal Partition Chromatography. Nat. Prod. Commun., 12 (2): 241-244.
  113. Srimachai, S., Deveux, S., Demougeot, C., Kumphune, S., Ullrich, N.D., Niggli, E., Ingkaninan, K., Kamkaew, N., Scholfield, C.N., Tapechum, S., Chootip, K. (2017) Bacopa monnieriextract increases ratcoronary flow and protects againstmyocardial ischemia/reperfusion injury. BMC Complementary and Alternative Medicine17 :117 DOI 10.1186/s12906-017-1637-z.
  114. Srivilai, J., Rabgay, K., Khorana, N., Waranuch, N., Nuengchamnong, N., Wisuitiprot, W., Chuprajob, T., Changtam, C., Suksamrarn, A., Chavasiri, W., Sornkaew, N., Ingkaninan., K. (2017)Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors. Med.ChemRes.DOI 10.1007/s00044-017-1869-y.
  115. Sookying, S., Pekthong, D., Oo-puthinan, S., Nuengchamnong, N., Ingkaninan, K. (2017) Quantitation of bacopaside I in rat biological samples by LC-QTOF-MS/MS and its pharmacokinetic application. Nat. Prod. Commun.12: 893-896.
  116. Onlom, C., Phrompittayarat, W., Putalun, W., Waranuch N., Ingkaninan K.(2017) Immunoaffinity knockout of saponin glycosides from Asparagus racemosusto assess anti-lipid peroxidation. Phytochem. Anal. 28(4):316-323.
  117. Yamchuen, P., Chaiwiang, N., Lapphanichayakool, P., Ingkaninan, K., Limpeanchob, N. (2017) Neuroprotective effect of Bacopa monnieri extract on oxidizedlow density lipoprotein-induced neurotoxicity in SH-SY5Yneuroblastoma cells. Thai J Pharmacol 39 (1), 5-18.
  118. Changwichit, K., Girard-Thernier, C, Temkitthawon, P., Khorana, N., Ingkaninan, K. (2018) Quantitative analysis of a phenanthrene from Eulophiaspecies by TLC-image analysis method. In press.
  119. Engsuwan, J., Waranuch, N., Limpeanchob, N., Ingkaninan, K. (2017) HPLC Methods for Quality Control of Moringa oleifera Extract using Isothiocyanates and Astragalin as Bioactive Markers. ScienceAsia. In press.

 

 

Petit-Patent

  1. Title: Preparation of enriched saponin extract from Bacopa monnieri

Inventors: Kornkanok Ingkaninan and Watoo Phrompittayarat

Patent No: 4081

  1. Title: Day cream containing of astaxanthin and Changkra extract

Inventors: Neti Waranuch and Kornkanok Ingkaninan

Patent No: 10384

  1. Title: Hand lotion containing of astaxanthin and Changkra extract

Inventors: Neti Waranuch and Kornkanok Ingkaninan

Patent No: 10385

  1. Title: Changkra perfume

Inventors: Neti Waranuch and Kornkanok Ingkaninan

Patent No: 10157

  1. Title: Cleansing hand gel containing of astaxanthin and Changkra extract

Inventors: Neti Waranuch and Kornkanok Ingkaninan

Patent No: 10512

  1. Title: Eye serum with Changkra aroma

Inventors: Kornkanok Ingkaninan, Pinyupa Plianbangchang and Neti Waranuch

Patent No: 10816

  1. Title: Night cream with Changkra aroma

Inventors: Kornkanok Ingkaninan, Pinyupa Plianbangchang and Neti Waranuch

Patent No: 10817

  1. Title: Shampoo containing of Wan Mahamek extract

Inventors: Neti Waranuch, Kornkanok Ingkaninan, Teerawuth Pomked

Patent No: 11481

  1. Title: Hair conditioner containing of Wan Mahamek extract

Inventors: Neti Waranuch Kornkanok Ingkaninan, Teerawuth Pomked

Patent No: 11482

  1. Title: Hair tonic containing of Wan Mahamek extract

Inventors: Neti Waranuch, Kornkanok Ingkaninan, Teerawuth Pomked

Patent No: 11600

  1. Title: Preparation of enriched phenanthrene extract from Eulophiaspp.

Inventors: Kornkanok Ingkaninan, Prapapan Temkitthawon, Kanokwang Changwichit

Patent No: 11835

  1. Title: Preparation method of SamedKao powdered extract

Inventors: Watoo Phrompittayarat, Neti Waranuch, Kornkanok Ingkaninan, Nantaka Khorana, Supaporn Lamlerdton

Patent No: 12018

  1. Title: Anti-cellulite herbal compress formulation

Inventors: Kornkanok Ingkaninan, Neti Waranuch, Krongkarn Chootip, Ngamrayu Ngamdokmai, Nitra Neungchamnong, Katechan Jampachaisri

Patent No: 12872

 

 

 

Awards

  1. Naresuan University Award for Outstanding Staff. 2003 By Naresuan University, Phitsanulok, Thailand
  2. Naresuan University Research Award 2005 By Naresuan University, Phitsanulok, Thailand
  3. Pharmacy Award for Academic and Research and Development. 2008. By Northern Pharmacy Community.
  4. Naresuan UniversityResearch Award 2009 By Naresuan University, Phitsanulok, Thailand
  5. Research Award 2011 By Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand
  6. Naresuan University Research Award; NU Outstanding Research Team2011 By Naresuan University, Phitsanulok, Thailand
  7. Outstanding Civil ServantAward 2013 By Thai Government
  8. Silver medal: The innovation “Brahmi tablet: a food supplement for memory improvement”Geneva Innovation 2014 (Palexpo, Geneva, Switzerland 2-6April 2014)
  9. Silver medal: The innovation “Hair growth control products from a Thai medicinal plant” Geneva Innovation 2014 (Palexpo, Geneva, Switzerland 2-6April 2014))
  10. Bronze medal: The innovation “The anti-wrinkle cosmeticscontaining green tea extract in microparticle” By Neti Waranuch, Kornkanok Ingkaninan and Wuttichai Wisuitiprot. Geneva Innovation 2014 (Palexpo, Geneva, Switzerland 2-6April 2014)and a special prize fromAssociation of Polish Inventors and Rationalizers
  11. JIPA Award: The Best Innovation in Biotechnology fromJapan Intellectual Property Association (JIPA) for the innovation “Hair growth control products from a Thai medicinal plant” Thailand Innovation 2014 (MuangTong Tani, Bangkok, Thailand, 23-26 June 2014).
  12. NRCT research award 2014. “The research and development of Brahmi for memory improvement”
  13. International Award from Naresuan Research Conference 11“Research and Innovation” 22-23 July, 2015.
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Bromo Conference
Symposium on Natural Products and Biodiversity in conjuction with Congress (13th) and Symposium (17th)
of The Indonesian Association of Natural Drug Researchers (PERHIPBA)
11 - 12 July 2018 - Surabaya , Indonesia